Stem cell therapy for glaucoma: Possibilities and practicalities

Thomas Johnson, Natalie D. Bull, Keith R. Martin

Research output: Contribution to journalArticle

Abstract

Glaucoma is a progressive, neurodegenerative, optic neuropathy in which currently available therapies cannot always prevent, and do not reverse, vision loss. Stem cell transplantation may provide a promising new avenue for treating many presently incurable degenerative conditions, including glaucoma. This article will explore the various ways in which transplantation of stem or progenitor cells may be applied for the treatment of glaucoma. We will critically discuss the translational prospects of two cell transplantation-based treatment modalities: neuroprotection and retinal ganglion cell replacement. In addition, we will identify specific questions that need to be addressed and obstacles to overcome on the path to clinical translation, and offer insight into potential strategies for approaching this goal.

Original languageEnglish (US)
Pages (from-to)165-174
Number of pages10
JournalExpert Review of Ophthalmology
Volume6
Issue number2
DOIs
StatePublished - Apr 1 2011

Fingerprint

Cell- and Tissue-Based Therapy
Stem cells
Glaucoma
Optics
Stem Cells
Optic Nerve Diseases
Critical Pathways
Retinal Ganglion Cells
Cell Transplantation
Stem Cell Transplantation
Therapeutics
Transplantation

Keywords

  • cell replacement
  • glaucoma
  • neuroprotection
  • optic nerve
  • progenitor cell
  • retinal ganglion cell
  • stem cell
  • transplantation

ASJC Scopus subject areas

  • Biomedical Engineering
  • Ophthalmology
  • Optometry

Cite this

Stem cell therapy for glaucoma : Possibilities and practicalities. / Johnson, Thomas; Bull, Natalie D.; Martin, Keith R.

In: Expert Review of Ophthalmology, Vol. 6, No. 2, 01.04.2011, p. 165-174.

Research output: Contribution to journalArticle

Johnson, Thomas ; Bull, Natalie D. ; Martin, Keith R. / Stem cell therapy for glaucoma : Possibilities and practicalities. In: Expert Review of Ophthalmology. 2011 ; Vol. 6, No. 2. pp. 165-174.
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