Stem Cell Theory and Inflammation-Related Cancer

Toshihiko Tanno, William Matsui

Research output: Chapter in Book/Report/Conference proceedingChapter


The factors responsible for the development of cancer stem cells and their subsequent regulation are unclear, but many of the processes induced by chronic inflammatory states are important regulators of normal stem cells. Thus, inflammation and the cellular responses required to adapt to the inflammatory state leads to generation of cancer stem cells and/or regulate their functional properties. This chapter discusses how these processes may become subverted to enhance the development and function of cancer stem cells. The association between chronic inflammation and an increased risk of cancer is well recognized. Several factors involved in chronic inflammation, including inflammatory cytokines, increased reactive oxygen species (ROS) levels, hypoxia, and the activation of developmental signaling pathway, have been associated with both carcinogenesis and normal stem cell regulation. Furthermore, emerging evidence suggests that these factors also play a role in regulating cancer stem cells.

Original languageEnglish (US)
Title of host publicationCancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects
PublisherWiley Blackwell
Number of pages14
ISBN (Print)9781118826621, 9781118160305
StatePublished - Mar 31 2014


  • Cancer stem cells
  • Chronic inflammation
  • Hypoxia
  • Inflammation
  • Inflammatory cytokines
  • Reactive oxygen species (ROS) levels
  • Stem cell theory

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Nursing(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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