Stem cell sources and their potential for the treatment of retinal degenerations

Valeria Canto-Soler, Miguel Flores-Bellver, M. Natalia Vergara

Research output: Contribution to journalArticle

Abstract

Stem cells offer unprecedented opportunities for the development of strategies geared toward the treatment of retinal degenerative diseases. A variety of cellular sources have been investigated for various potential clinical applications, including tissue regeneration, disease modeling, and screening for non–cell-based therapeutic agents. As the field transitions from more than a decade of preclinical research to the first phase I/II clinical trials, we provide a concise overview of the stem cell sources most commonly used, weighing their therapeutic potential on the basis of their technical strengths/limitations, their ethical implications, and the extent of the progress achieved to date. This article serves as a framework for further indepth analyses presented in the following chapters of this Special Issue.

Original languageEnglish (US)
Pages (from-to)ORSFd1-ORSFd9
JournalInvestigative Ophthalmology and Visual Science
Volume57
Issue number5
DOIs
StatePublished - Apr 1 2016

Fingerprint

Retinal Degeneration
Stem Cells
Retinal Diseases
Phase II Clinical Trials
Clinical Trials, Phase I
Regeneration
Therapeutics
Research

Keywords

  • Retinal degeneration
  • Stem cells
  • Therapies

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Stem cell sources and their potential for the treatment of retinal degenerations. / Canto-Soler, Valeria; Flores-Bellver, Miguel; Vergara, M. Natalia.

In: Investigative Ophthalmology and Visual Science, Vol. 57, No. 5, 01.04.2016, p. ORSFd1-ORSFd9.

Research output: Contribution to journalArticle

Canto-Soler, Valeria ; Flores-Bellver, Miguel ; Vergara, M. Natalia. / Stem cell sources and their potential for the treatment of retinal degenerations. In: Investigative Ophthalmology and Visual Science. 2016 ; Vol. 57, No. 5. pp. ORSFd1-ORSFd9.
@article{089c490691b043f08e380cfc7ac98c81,
title = "Stem cell sources and their potential for the treatment of retinal degenerations",
abstract = "Stem cells offer unprecedented opportunities for the development of strategies geared toward the treatment of retinal degenerative diseases. A variety of cellular sources have been investigated for various potential clinical applications, including tissue regeneration, disease modeling, and screening for non–cell-based therapeutic agents. As the field transitions from more than a decade of preclinical research to the first phase I/II clinical trials, we provide a concise overview of the stem cell sources most commonly used, weighing their therapeutic potential on the basis of their technical strengths/limitations, their ethical implications, and the extent of the progress achieved to date. This article serves as a framework for further indepth analyses presented in the following chapters of this Special Issue.",
keywords = "Retinal degeneration, Stem cells, Therapies",
author = "Valeria Canto-Soler and Miguel Flores-Bellver and Vergara, {M. Natalia}",
year = "2016",
month = "4",
day = "1",
doi = "10.1167/iovs.16-19127",
language = "English (US)",
volume = "57",
pages = "ORSFd1--ORSFd9",
journal = "Investigative Ophthalmology and Visual Science",
issn = "0146-0404",
publisher = "Association for Research in Vision and Ophthalmology Inc.",
number = "5",

}

TY - JOUR

T1 - Stem cell sources and their potential for the treatment of retinal degenerations

AU - Canto-Soler, Valeria

AU - Flores-Bellver, Miguel

AU - Vergara, M. Natalia

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Stem cells offer unprecedented opportunities for the development of strategies geared toward the treatment of retinal degenerative diseases. A variety of cellular sources have been investigated for various potential clinical applications, including tissue regeneration, disease modeling, and screening for non–cell-based therapeutic agents. As the field transitions from more than a decade of preclinical research to the first phase I/II clinical trials, we provide a concise overview of the stem cell sources most commonly used, weighing their therapeutic potential on the basis of their technical strengths/limitations, their ethical implications, and the extent of the progress achieved to date. This article serves as a framework for further indepth analyses presented in the following chapters of this Special Issue.

AB - Stem cells offer unprecedented opportunities for the development of strategies geared toward the treatment of retinal degenerative diseases. A variety of cellular sources have been investigated for various potential clinical applications, including tissue regeneration, disease modeling, and screening for non–cell-based therapeutic agents. As the field transitions from more than a decade of preclinical research to the first phase I/II clinical trials, we provide a concise overview of the stem cell sources most commonly used, weighing their therapeutic potential on the basis of their technical strengths/limitations, their ethical implications, and the extent of the progress achieved to date. This article serves as a framework for further indepth analyses presented in the following chapters of this Special Issue.

KW - Retinal degeneration

KW - Stem cells

KW - Therapies

UR - http://www.scopus.com/inward/record.url?scp=84964519925&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84964519925&partnerID=8YFLogxK

U2 - 10.1167/iovs.16-19127

DO - 10.1167/iovs.16-19127

M3 - Article

VL - 57

SP - ORSFd1-ORSFd9

JO - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

SN - 0146-0404

IS - 5

ER -