TY - JOUR
T1 - Stem cell sources and their potential for the treatment of retinal degenerations
AU - Canto-Soler, Valeria
AU - Flores-Bellver, Miguel
AU - Vergara, M. Natalia
N1 - Funding Information:
Supported in part by National Eye Institute Grant R01EY022631, the William & Mary Greve Special Scholar Award from Research to Prevent Blindness, and an honorarium from the Ocular Research Symposium Foundation.
Publisher Copyright:
© 2015 Association for Research in Vision and Ophthalmology.
PY - 2016/4
Y1 - 2016/4
N2 - Stem cells offer unprecedented opportunities for the development of strategies geared toward the treatment of retinal degenerative diseases. A variety of cellular sources have been investigated for various potential clinical applications, including tissue regeneration, disease modeling, and screening for non–cell-based therapeutic agents. As the field transitions from more than a decade of preclinical research to the first phase I/II clinical trials, we provide a concise overview of the stem cell sources most commonly used, weighing their therapeutic potential on the basis of their technical strengths/limitations, their ethical implications, and the extent of the progress achieved to date. This article serves as a framework for further indepth analyses presented in the following chapters of this Special Issue.
AB - Stem cells offer unprecedented opportunities for the development of strategies geared toward the treatment of retinal degenerative diseases. A variety of cellular sources have been investigated for various potential clinical applications, including tissue regeneration, disease modeling, and screening for non–cell-based therapeutic agents. As the field transitions from more than a decade of preclinical research to the first phase I/II clinical trials, we provide a concise overview of the stem cell sources most commonly used, weighing their therapeutic potential on the basis of their technical strengths/limitations, their ethical implications, and the extent of the progress achieved to date. This article serves as a framework for further indepth analyses presented in the following chapters of this Special Issue.
KW - Retinal degeneration
KW - Stem cells
KW - Therapies
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U2 - 10.1167/iovs.16-19127
DO - 10.1167/iovs.16-19127
M3 - Article
C2 - 27116661
AN - SCOPUS:84964519925
SN - 0146-0404
VL - 57
SP - ORSFd1-ORSFd9
JO - Investigative Ophthalmology and Visual Science
JF - Investigative Ophthalmology and Visual Science
IS - 5
ER -