Stem cell sources and their potential for the treatment of retinal degenerations

Valeria Canto-Soler, Miguel Flores-Bellver, M. Natalia Vergara

Research output: Contribution to journalArticle

Abstract

Stem cells offer unprecedented opportunities for the development of strategies geared toward the treatment of retinal degenerative diseases. A variety of cellular sources have been investigated for various potential clinical applications, including tissue regeneration, disease modeling, and screening for non–cell-based therapeutic agents. As the field transitions from more than a decade of preclinical research to the first phase I/II clinical trials, we provide a concise overview of the stem cell sources most commonly used, weighing their therapeutic potential on the basis of their technical strengths/limitations, their ethical implications, and the extent of the progress achieved to date. This article serves as a framework for further indepth analyses presented in the following chapters of this Special Issue.

Original languageEnglish (US)
Pages (from-to)ORSFd1-ORSFd9
JournalInvestigative Ophthalmology and Visual Science
Volume57
Issue number5
DOIs
StatePublished - Apr 1 2016

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Keywords

  • Retinal degeneration
  • Stem cells
  • Therapies

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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