Stem cell self-organization into mature neuronal tissue in subarachnoid space

Ao Hu-Shan, Qu Yun, John W. McDonald

Research output: Contribution to journalArticle

Abstract

Embryonic stem (ES) cells might one day be used to repair damaged organs. In the normal embryo, they have the unique ability to self-organize into spatially appropriate arrangements of cells, but this capacity has not been demonstrated outside of embryonic development. Here we report that ES cells transplanted into the subarachnoid space of the normal adult rat spinal cord self -organized into CNS-like tissue with features resembling rat cord. By 3 months after transplantation, the grafts contained primarily the three principle neural cell types: astrocytes, oligodendrocytes, and neurons. ES astrocytes had created a glial limitans resembling the layer covering the normal cord, ES oligodendrocytes had produced mature patterns of myelination, and ES neurons exhibited features of cholinergic motor neurons.

Original languageEnglish (US)
Pages (from-to)15-21
Number of pages7
JournalJournal of Chinese Clinical Medicine
Volume6
Issue number1
StatePublished - Jan 2011

Fingerprint

Subarachnoid Space
Oligodendroglia
Embryonic Stem Cells
Astrocytes
Stem Cells
Neurons
Cholinergic Neurons
Motor Neurons
Neuroglia
Embryonic Development
Spinal Cord
Embryonic Structures
Transplantation
Transplants

Keywords

  • Neural transplantation
  • Rat
  • Regeneration
  • Repair
  • Stem cells

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Stem cell self-organization into mature neuronal tissue in subarachnoid space. / Hu-Shan, Ao; Yun, Qu; McDonald, John W.

In: Journal of Chinese Clinical Medicine, Vol. 6, No. 1, 01.2011, p. 15-21.

Research output: Contribution to journalArticle

Hu-Shan, Ao ; Yun, Qu ; McDonald, John W. / Stem cell self-organization into mature neuronal tissue in subarachnoid space. In: Journal of Chinese Clinical Medicine. 2011 ; Vol. 6, No. 1. pp. 15-21.
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