Stem cell plasticity: A rare cell, not a rare event

Yoon Young Jang, Saul J. Sharkis

Research output: Contribution to journalReview articlepeer-review

Abstract

Purification to homogeneity for a rare stem cell (SC) population by both function and phenotype is a prerequisite to determine if SCs can change their fate (plasticity). Since cell fate determination has been suggested by both external environmental cues and intrinsic gene regulation, plasticity should be studied using both influences. Different frequencies of marrow SC plasticity may be attributed to either different isolation technologies or different developmental stage SCs with more or less multipotentiality. Tissue-specific SCs may reside in marrow, or alternatively, primitive marrow SC may respond directly to regenerative signals by migration to injury sites and repairing the damaged tissue. It is important to dissect the relationship between primitive/tissue-specific SCs and regenerative signals.

Original languageEnglish (US)
Pages (from-to)45-51
Number of pages7
JournalStem Cell Reviews
Volume1
Issue number1
DOIs
StatePublished - Mar 2005

Keywords

  • Cell fate change
  • Marrow stem cell
  • Plasticity
  • Regenerative signals
  • Tissue-specific stem cell

ASJC Scopus subject areas

  • Medicine(all)

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