Stem cell factor, interleukin-16, and interleukin-2 receptor alpha are predictive biomarkers for delayed and slow graft function

N. Alachkar, R. Ugarte, E. Huang, K. L. Womer, R. Montgomery, E. Kraus, H. Rabb

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction Delayed graft function (DGF) and slow graft function (SGF) due to ischemic and reperfusion injury (IRI) are common complications of deceased donor kidney transplantation. We tested whether a panel of serum and urine cytokines represent early biomarkers for DGF and SGF. Methods We collected serum and urine samples from 61 patients 48 hours posttransplantation and used a multiplex enzyme-linked immunosorbent assay (ELISA) technique to measure levels of 23 cytokines. Fourteen patients developed poor graft function (PGF), with 6 having DGF and 8 with SGF. Results Area under receiver operation characteristics curve (AUC) demonstrated the following: serum levels of SCF (0.88) and interleukin (IL) 16 (0.74). Conclusions This study showed that a select panel of cytokines measured early post kidney transplantation may predict poor graft function.

Original languageEnglish (US)
Pages (from-to)3399-3405
Number of pages7
JournalTransplantation proceedings
Volume42
Issue number9
DOIs
StatePublished - Nov 2010

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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