Stem cell competition: Finding balance in the niche

Rachel R. Stine, Erika L. Matunis

Research output: Contribution to journalReview articlepeer-review

Abstract

Adult stem cells reside in local microenvironments (niches) that produce signals regulating the outcome of stem cell divisions and stem cell-niche interactions. Limited space and signals in the niche often force stem cells to compete with one another. Although previous studies have uncovered several examples of genetically distinct stem cells competing for niche access, recent studies demonstrate that genetically equivalent stem cells compete under normal conditions, resulting in dynamic stem cell behavior in the niche. New work in multiple vertebrate and invertebrate tissues shows that stem cell competition occurs continuously and mutations disrupting the balance between competing stem cells can cause diseases and defects in the niche. This review discusses recent insights into stem cell competition in mammals and Drosophila.

Original languageEnglish (US)
Pages (from-to)357-364
Number of pages8
JournalTrends in Cell Biology
Volume23
Issue number8
DOIs
StatePublished - Aug 1 2013

Keywords

  • Cancer
  • Competition
  • Niche
  • Stem cell

ASJC Scopus subject areas

  • Cell Biology

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