Steep Rebound of Chloroquine-Sensitive Plasmodium falciparum in Zimbabwe

Sungano Mharakurwa, Zvifadzo Matsena-Zingoni, Nobert Mudare, Charmaine Matimba, Tanatswa Xuxa Gara, Aramu Makuwaza, Gladys Maponga, Shungu Munyati, Lovemore Gwanzura, Susan L. Mutambu, Peter Mason, Tamaki Kobayashi, Nicholas Midzi, William J. Moss, Matthew M. Ippolito

Research output: Contribution to journalArticlepeer-review

Abstract

Removal of chloroquine from national malaria formularies can lead to the reversion of resistant Plasmodium falciparum to wild-type. We report a steep decline in chloroquine-resistant P falciparum within 10 years of national discontinuation of chloroquine monotherapy in Zimbabwe. Drug resistance surveillance is a vital component of malaria control programs, and the experience with chloroquine in Zimbabwe and elsewhere in sub-Saharan Africa is illustrative of the potentially rapid and dramatic impact of drug policy on antimalarial resistance.

Original languageEnglish (US)
Pages (from-to)306-309
Number of pages4
JournalThe Journal of infectious diseases
Volume223
Issue number2
DOIs
StatePublished - Feb 3 2021

Keywords

  • Plasmodium falciparum
  • chloroquine
  • drug resistance
  • malaria
  • Zimbabwe

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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