Steep left ventricle to aortic root angle and hypertrophic obstructive cardiomyopathy: Study of a novel association using three-dimensional multimodality imaging

D. H. Kwon, N. G. Smedira, Z. B. Popovic, B. W. Lytle, R. M. Setser, M. Thamilarasan, P. Schoenhagen, S. D. Flamm, H. M. Lever, M. Y. Desai

Research output: Contribution to journalArticle

Abstract

Background: Patients with hypertrophic cardiomyopathy (HCM) exhibit a difference in left ventricular outflow tract (LVOT) obstruction, independently of basal septal thickness (BST). Some patients with HCM have a steeper left ventricle to aortic root angle than controls. Objective: To test the predictors of the LV-aortic root angle and the association between LV-aortic root angle and LVOT obstruction using three-dimensional imaging. Patients: 153 consecutive patients with HCM (mean (SD) age 46 (14) years, 68% men) and 62 patients with hypertensive heart disease of the elderly (all >65 years of age, 73 (6) years, 34% men) who underwent whole-heart three-dimensional cardiac magnetic resonance (CMR) angiography (1.5 T) and Doppler echocardiography. Forty-two controls (age 43 (11) years, 38% men) who underwent contrast-enhanced multidetector computed tomography and were free of cardiovascular pathology were also studied. Main outcomes: LV-aortic root angle, BST and maximal non-exercise LVOT gradient were measured in patients with HCM and in hypertensive-elderly patients. Additionally, LV-aortic root angle and BST were measured in controls. Results: The mean (SD) LV-aortic root angle was significantly different (p

Original languageEnglish (US)
Pages (from-to)1784-1791
Number of pages8
JournalHeart
Volume95
Issue number21
DOIs
Publication statusPublished - Nov 2009
Externally publishedYes

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Kwon, D. H., Smedira, N. G., Popovic, Z. B., Lytle, B. W., Setser, R. M., Thamilarasan, M., ... Desai, M. Y. (2009). Steep left ventricle to aortic root angle and hypertrophic obstructive cardiomyopathy: Study of a novel association using three-dimensional multimodality imaging. Heart, 95(21), 1784-1791. https://doi.org/10.1136/hrt.2009.166777