Steatorrhea and hyperoxaluria occur after gastric bypass surgery in obese rats regardless of dietary fat or oxalate

Benjamin K. Canales, Joseph Ellen, Saeed R. Khan, Marguerite Hatch

Research output: Contribution to journalArticle

Abstract

Purpose: We determined the effect of dietary fat and oxalate on fecal fat excretion and urine parameters in a rat model of Roux-en-Y gastric bypass surgery. Materials and Methods: Diet induced obese Sprague-Dawley® rats underwent sham surgery as controls (16), or Roux-en-Y gastric bypass surgery (19). After recovery, rats had free access to a normal calcium, high fat (40%) diet with or without 1.5% potassium oxalate for 5 weeks and then a normal (10%) fat diet for 2 weeks. Stool and urine were collected after each period. Fecal fat was determined by gas chromatography and urine metabolites were evaluated by assay spectrophotometry. Results: Daily fecal fat excretion remained low in controls on either diet. However, Roux-en-Y gastric bypass rats ingested a food quantity similar to that of controls but had eightfold higher fecal fat excretion (p

Original languageEnglish (US)
Pages (from-to)1102-1109
Number of pages8
JournalJournal of Urology
Volume190
Issue number3
DOIs
StatePublished - Sep 2013
Externally publishedYes

Keywords

  • calcium oxalate
  • gastric bypass
  • morbid
  • obesity
  • steatorrhea
  • urinary bladder

ASJC Scopus subject areas

  • Urology

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