Steady state verapamil tissue distribution in the dog: Differing tissue accumulation

Janice B. Schwartz; Elizabeth Todd; Darrell B. Abernethy; Jerry R. Mitchell

doi:10.1159/000138185

Steady state verapamil tissue distribution in the dog: Differing tissue accumulation

Janice B. Schwartz, Elizabeth Todd, Darrell B. Abernethy, Jerry R. Mitchell

School of Medicine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Plasma, heart, and extracardiac tissue verapamil concentrations were measured after sustained intravenous infusions in 11 dogs to determine the differential tissue accumulation of verapamil. A steady state verapamil concentration of 327 ± 50 ng/ml decreased the mean arterial blood pressure from 104 ± 9 to 90 ± 6 mm Hg (p = 0.08) and the P-R interval increased from 118 ± 4 to 176 ± 13 ms (p < 0.001) with second-degree atrioventricular block developing in 6 animals. Verapamil accumulated in organs in the following order: Lung >> kidney > spleen > ventricular myocardium = liver > atrial myocardium > cerebral cortex > fat = skeletal muscle. Levels in the ventricular free wall were consistently greater than atrial levels, but no difference was observed between left versus right-sided cardiac chambers. In summary, affinity of different organs for verapamil is highly variable and organ-specific; furthermore, differential intracardiac chamber accumulation occurs.

Original language	English (US)
Pages (from-to)	307-312
Number of pages	6
Journal	Pharmacology
Volume	32
Issue number	6
DOIs	https://doi.org/10.1159/000138185
State	Published - 1986

Keywords

Cardiac verapamil concentrations
Tissue concentrations
Verapamil

ASJC Scopus subject areas

Pharmacology

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10.1159/000138185

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@article{7eb73fb2d69d4e878c1e9df38cf972c1,

title = "Steady state verapamil tissue distribution in the dog: Differing tissue accumulation",

abstract = "Plasma, heart, and extracardiac tissue verapamil concentrations were measured after sustained intravenous infusions in 11 dogs to determine the differential tissue accumulation of verapamil. A steady state verapamil concentration of 327 ± 50 ng/ml decreased the mean arterial blood pressure from 104 ± 9 to 90 ± 6 mm Hg (p = 0.08) and the P-R interval increased from 118 ± 4 to 176 ± 13 ms (p < 0.001) with second-degree atrioventricular block developing in 6 animals. Verapamil accumulated in organs in the following order: Lung >> kidney > spleen > ventricular myocardium = liver > atrial myocardium > cerebral cortex > fat = skeletal muscle. Levels in the ventricular free wall were consistently greater than atrial levels, but no difference was observed between left versus right-sided cardiac chambers. In summary, affinity of different organs for verapamil is highly variable and organ-specific; furthermore, differential intracardiac chamber accumulation occurs.",

keywords = "Cardiac verapamil concentrations, Tissue concentrations, Verapamil",

author = "Schwartz, {Janice B.} and Elizabeth Todd and Abernethy, {Darrell B.} and Mitchell, {Jerry R.}",

year = "1986",

doi = "10.1159/000138185",

language = "English (US)",

volume = "32",

pages = "307--312",

journal = "Pharmacology",

issn = "0031-7012",

publisher = "S. Karger AG",

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TY - JOUR

T1 - Steady state verapamil tissue distribution in the dog

T2 - Differing tissue accumulation

AU - Schwartz, Janice B.

AU - Todd, Elizabeth

AU - Abernethy, Darrell B.

AU - Mitchell, Jerry R.

PY - 1986

Y1 - 1986

N2 - Plasma, heart, and extracardiac tissue verapamil concentrations were measured after sustained intravenous infusions in 11 dogs to determine the differential tissue accumulation of verapamil. A steady state verapamil concentration of 327 ± 50 ng/ml decreased the mean arterial blood pressure from 104 ± 9 to 90 ± 6 mm Hg (p = 0.08) and the P-R interval increased from 118 ± 4 to 176 ± 13 ms (p < 0.001) with second-degree atrioventricular block developing in 6 animals. Verapamil accumulated in organs in the following order: Lung >> kidney > spleen > ventricular myocardium = liver > atrial myocardium > cerebral cortex > fat = skeletal muscle. Levels in the ventricular free wall were consistently greater than atrial levels, but no difference was observed between left versus right-sided cardiac chambers. In summary, affinity of different organs for verapamil is highly variable and organ-specific; furthermore, differential intracardiac chamber accumulation occurs.

AB - Plasma, heart, and extracardiac tissue verapamil concentrations were measured after sustained intravenous infusions in 11 dogs to determine the differential tissue accumulation of verapamil. A steady state verapamil concentration of 327 ± 50 ng/ml decreased the mean arterial blood pressure from 104 ± 9 to 90 ± 6 mm Hg (p = 0.08) and the P-R interval increased from 118 ± 4 to 176 ± 13 ms (p < 0.001) with second-degree atrioventricular block developing in 6 animals. Verapamil accumulated in organs in the following order: Lung >> kidney > spleen > ventricular myocardium = liver > atrial myocardium > cerebral cortex > fat = skeletal muscle. Levels in the ventricular free wall were consistently greater than atrial levels, but no difference was observed between left versus right-sided cardiac chambers. In summary, affinity of different organs for verapamil is highly variable and organ-specific; furthermore, differential intracardiac chamber accumulation occurs.

KW - Cardiac verapamil concentrations

KW - Tissue concentrations

KW - Verapamil

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ER -

Steady state verapamil tissue distribution in the dog: Differing tissue accumulation

Abstract

Keywords

ASJC Scopus subject areas

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