Steady state verapamil tissue distribution in the dog: Differing tissue accumulation

Janice B. Schwartz, Elizabeth Todd, Darrell B. Abernethy, Jerry R. Mitchell

Research output: Contribution to journalArticlepeer-review

Abstract

Plasma, heart, and extracardiac tissue verapamil concentrations were measured after sustained intravenous infusions in 11 dogs to determine the differential tissue accumulation of verapamil. A steady state verapamil concentration of 327 ± 50 ng/ml decreased the mean arterial blood pressure from 104 ± 9 to 90 ± 6 mm Hg (p = 0.08) and the P-R interval increased from 118 ± 4 to 176 ± 13 ms (p < 0.001) with second-degree atrioventricular block developing in 6 animals. Verapamil accumulated in organs in the following order: Lung >> kidney > spleen > ventricular myocardium = liver > atrial myocardium > cerebral cortex > fat = skeletal muscle. Levels in the ventricular free wall were consistently greater than atrial levels, but no difference was observed between left versus right-sided cardiac chambers. In summary, affinity of different organs for verapamil is highly variable and organ-specific; furthermore, differential intracardiac chamber accumulation occurs.

Original languageEnglish (US)
Pages (from-to)307-312
Number of pages6
JournalPharmacology
Volume32
Issue number6
DOIs
StatePublished - 1986

Keywords

  • Cardiac verapamil concentrations
  • Tissue concentrations
  • Verapamil

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Steady state verapamil tissue distribution in the dog: Differing tissue accumulation'. Together they form a unique fingerprint.

Cite this