Steady pulsed imaging and labeling scheme for noninvasive perfusion imaging

Jiadi Xu, Qin Qin, Dan Wu, Jun Hua, Xiaolei Song, Michael T Mcmahon, Frances Northington, Jiangyang Zhang, Peter C Van Zijl, James J Pekar

Research output: Contribution to journalArticle

Abstract

Purpose: A steady pulsed imaging and labeling (SPIL) scheme is proposed to obtain high-resolution multislice perfusion images of mice brain using standard preclinical MRI equipment. Theory and Methods: The SPIL scheme repeats a pulsed arterial spin labeling (PASL) module together with a short mixing time to extend the temporal duration of the generated PASL bolus to the total experimental time. Multislice image acquisition takes place during the mixing times. The mixing time is also used for magnetization recovery following image acquisition. The new scheme is able to yield multislice perfusion images rapidly. The perfusion kinetic curve can be measured by a multipulsed imaging and labeling (MPIL) scheme, i.e., acquiring single-slice ASL signals before reaching steady-state in the SPIL sequence. Results: When applying the SPIL method to normal mice, and to mice with unilateral ischemia, high-resolution multislice (five slices) CBF images could be obtained in 8 min. Perfusion data from ischemic mice showed clear CBF reductions in ischemic regions. The SPIL method was also applied to postmortem mice, showing that the method is free from magnetization transfer confounds. Conclusion: The new SPIL scheme provides for robust measurement of CBF with multislice imaging capability in small animals.

Original languageEnglish (US)
JournalMagnetic Resonance in Medicine
DOIs
StateAccepted/In press - 2015

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Perfusion Imaging
Perfusion
Ischemia
Equipment and Supplies
Brain

Keywords

  • Arterial spin labeling (ASL)
  • Cerebral blood flow (CBF)
  • Multipulsed imaging and labeling (MPIL)
  • Perfusion
  • Pulsed arterial spin labeling (PASL)
  • Steady pulsed imaging and labeling (SPIL)
  • Un-inverted flow-sensitive alternating inversion recovery (UNFAIR)

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Steady pulsed imaging and labeling scheme for noninvasive perfusion imaging. / Xu, Jiadi; Qin, Qin; Wu, Dan; Hua, Jun; Song, Xiaolei; Mcmahon, Michael T; Northington, Frances; Zhang, Jiangyang; Van Zijl, Peter C; Pekar, James J.

In: Magnetic Resonance in Medicine, 2015.

Research output: Contribution to journalArticle

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AU - Xu, Jiadi

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AU - Wu, Dan

AU - Hua, Jun

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AU - Mcmahon, Michael T

AU - Northington, Frances

AU - Zhang, Jiangyang

AU - Van Zijl, Peter C

AU - Pekar, James J

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