STE6, the yeast a-factor transporter

Research output: Contribution to journalArticlepeer-review

Abstract

In eukaryotic cells, most extracellular proteins exit the cell via the classical secretory pathway (ER→Golgi→secretory vesicles). A notable exception to this pattern is the Saccharomyces cerevisiae mating pheromone a-factor, an isoprenylated, methylated, oligopeptide signaling molecule which uses a distinctly non-classical mechanism for secretion. Export of a-factor from the yeast cell is mediated by STE6, a member of the ABC protein superfamily. STE6 is one of the few eukaryotic ABC proteins for which a true physiological substrate is known. The ability to carry out molecular manipulations with ease in yeast, together with the possibility of probing substrate-transporter interactions via genetic analysis, affords an excellent opportunity to rigorously dissect the workings of this ABC family member.

Original languageEnglish (US)
Pages (from-to)17-27
Number of pages11
JournalSeminars in Cell and Developmental Biology
Volume4
Issue number1
DOIs
StatePublished - Jan 1 1993

Keywords

  • A-factor
  • ABC protein
  • STE6
  • Transporter
  • Yeast pheromone

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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