Stavudine concentrations in women receiving postpartum antiretroviral treatment and their breastfeeding infants

Jessica M. Fogel, Taha E. Taha, Jin Sun, Donald R. Hoover, Teresa L. Parsons, Johnstone J. Kumwenda, Lynne M. Mofenson, Mary Glenn Fowler, Craig W. Hendrix, Newton I. Kumwenda, Susan H. Eshleman, Mark Mirochnick

Research output: Contribution to journalArticlepeer-review

Abstract

First-line antiretroviral treatment regimens in resource-limited settings used in breastfeeding mothers often include stavudine (d4T). Limited data describing d4T concentrations in breast milk are available. We analyzed d4T concentrations in 52 mother-infant pairs using ultra-performance liquid chromatography-tandem mass spectrometry (lower limit of quantification: 5 ng/mL in plasma, 20 ng/mL in breast milk). Median (interquartile range) d4T concentrations were 86 (36-191) ng/mL in maternal plasma, 151 (48-259) ng/mL in whole milk, 190 (58-296) ng/mL in skim milk, and <5 (<5 to <5) ng/mL in infant plasma. Although d4T is concentrated in breast milk relative to maternal plasma, the infant d4T dose received from breast milk is very small and not clinically significant.

Original languageEnglish (US)
Pages (from-to)462-465
Number of pages4
JournalJournal of acquired immune deficiency syndromes
Volume60
Issue number5
DOIs
StatePublished - Aug 15 2012

Keywords

  • HIV
  • breast milk
  • mother-to-child transmission
  • stavudine concentrations

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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