Stavudine concentrations in women receiving postpartum antiretroviral treatment and their breastfeeding infants

Jessica M. Fogel; Taha E. Taha; Jin Sun; Donald R. Hoover; Teresa L. Parsons; Johnstone J. Kumwenda; Lynne M. Mofenson; Mary Glenn Fowler; Craig W. Hendrix; Newton I. Kumwenda; Susan H. Eshleman; Mark Mirochnick

doi:10.1097/QAI.0b013e31825ddcfa

Stavudine concentrations in women receiving postpartum antiretroviral treatment and their breastfeeding infants

Jessica M. Fogel, Taha E. Taha, Jin Sun, Donald R. Hoover, Teresa L. Parsons, Johnstone J. Kumwenda, Lynne M. Mofenson, Mary Glenn Fowler, Craig W. Hendrix, Newton I. Kumwenda, Susan H. Eshleman, Mark Mirochnick

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

First-line antiretroviral treatment regimens in resource-limited settings used in breastfeeding mothers often include stavudine (d4T). Limited data describing d4T concentrations in breast milk are available. We analyzed d4T concentrations in 52 mother-infant pairs using ultra-performance liquid chromatography-tandem mass spectrometry (lower limit of quantification: 5 ng/mL in plasma, 20 ng/mL in breast milk). Median (interquartile range) d4T concentrations were 86 (36-191) ng/mL in maternal plasma, 151 (48-259) ng/mL in whole milk, 190 (58-296) ng/mL in skim milk, and <5 (<5 to <5) ng/mL in infant plasma. Although d4T is concentrated in breast milk relative to maternal plasma, the infant d4T dose received from breast milk is very small and not clinically significant.

Original language	English (US)
Pages (from-to)	462-465
Number of pages	4
Journal	Journal of Acquired Immune Deficiency Syndromes
Volume	60
Issue number	5
DOIs	https://doi.org/10.1097/QAI.0b013e31825ddcfa
State	Published - Aug 15 2012

Keywords

HIV
breast milk
mother-to-child transmission
stavudine concentrations

ASJC Scopus subject areas

Infectious Diseases
Pharmacology (medical)

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10.1097/QAI.0b013e31825ddcfa

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Fogel, J. M., Taha, T. E., Sun, J., Hoover, D. R., Parsons, T. L., Kumwenda, J. J., Mofenson, L. M., Fowler, M. G., Hendrix, C. W., Kumwenda, N. I., Eshleman, S. H., & Mirochnick, M. (2012). Stavudine concentrations in women receiving postpartum antiretroviral treatment and their breastfeeding infants. Journal of Acquired Immune Deficiency Syndromes, 60(5), 462-465. https://doi.org/10.1097/QAI.0b013e31825ddcfa

Fogel, JM, Taha, TE, Sun, J, Hoover, DR, Parsons, TL, Kumwenda, JJ, Mofenson, LM, Fowler, MG , Hendrix, CW, Kumwenda, NI, Eshleman, SH & Mirochnick, M 2012, 'Stavudine concentrations in women receiving postpartum antiretroviral treatment and their breastfeeding infants', Journal of Acquired Immune Deficiency Syndromes, vol. 60, no. 5, pp. 462-465. https://doi.org/10.1097/QAI.0b013e31825ddcfa

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abstract = "First-line antiretroviral treatment regimens in resource-limited settings used in breastfeeding mothers often include stavudine (d4T). Limited data describing d4T concentrations in breast milk are available. We analyzed d4T concentrations in 52 mother-infant pairs using ultra-performance liquid chromatography-tandem mass spectrometry (lower limit of quantification: 5 ng/mL in plasma, 20 ng/mL in breast milk). Median (interquartile range) d4T concentrations were 86 (36-191) ng/mL in maternal plasma, 151 (48-259) ng/mL in whole milk, 190 (58-296) ng/mL in skim milk, and <5 (<5 to <5) ng/mL in infant plasma. Although d4T is concentrated in breast milk relative to maternal plasma, the infant d4T dose received from breast milk is very small and not clinically significant.",

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author = "Fogel, {Jessica M.} and Taha, {Taha E.} and Jin Sun and Hoover, {Donald R.} and Parsons, {Teresa L.} and Kumwenda, {Johnstone J.} and Mofenson, {Lynne M.} and Fowler, {Mary Glenn} and Hendrix, {Craig W.} and Kumwenda, {Newton I.} and Eshleman, {Susan H.} and Mark Mirochnick",

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AU - Kumwenda, Johnstone J.

AU - Mofenson, Lynne M.

AU - Fowler, Mary Glenn

AU - Hendrix, Craig W.

AU - Kumwenda, Newton I.

AU - Eshleman, Susan H.

AU - Mirochnick, Mark

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Stavudine concentrations in women receiving postpartum antiretroviral treatment and their breastfeeding infants

Abstract

Keywords

ASJC Scopus subject areas

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