Status of in vitro ocular irritation testing

Alan Goldberg, P. M. Silber

Research output: Contribution to journalArticle

Abstract

This paper reviews advances in the validation of alternative methods for eye irritation testing since the 1987 publication, A Critical Evaluation of Alternatives to Acute Ocular Irritation Testing (1). We have highlighted details of methods that appear promising and identified the minimum needs and endpoints necessary to develop a battery or batteries of in vitro tests to evaluate eye irritancy. We have recommended a series of workshops to provide identified batteries for specific classes of chemicals or for specific uses of eye irritancy testing. We have also identified the need for consensus meetings and peer-reviewed publication to ensure that the most predictive batteries become parts of validation studies. Finally, we note that academic scientists, industry, government and the animal protection community must work together in order to replace in vivo eye irritancy testing with appropriately validated in vitro methods.

Original languageEnglish (US)
Pages (from-to)161-192
Number of pages32
JournalLens and Eye Toxicity Research
Volume9
Issue number3-4
StatePublished - 1992

Fingerprint

Publications
Validation Studies
Industry
In Vitro Techniques
Education

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

Cite this

Status of in vitro ocular irritation testing. / Goldberg, Alan; Silber, P. M.

In: Lens and Eye Toxicity Research, Vol. 9, No. 3-4, 1992, p. 161-192.

Research output: Contribution to journalArticle

Goldberg, Alan ; Silber, P. M. / Status of in vitro ocular irritation testing. In: Lens and Eye Toxicity Research. 1992 ; Vol. 9, No. 3-4. pp. 161-192.
@article{c5af6fc51cbb4b748cf865b8bbeddcb0,
title = "Status of in vitro ocular irritation testing",
abstract = "This paper reviews advances in the validation of alternative methods for eye irritation testing since the 1987 publication, A Critical Evaluation of Alternatives to Acute Ocular Irritation Testing (1). We have highlighted details of methods that appear promising and identified the minimum needs and endpoints necessary to develop a battery or batteries of in vitro tests to evaluate eye irritancy. We have recommended a series of workshops to provide identified batteries for specific classes of chemicals or for specific uses of eye irritancy testing. We have also identified the need for consensus meetings and peer-reviewed publication to ensure that the most predictive batteries become parts of validation studies. Finally, we note that academic scientists, industry, government and the animal protection community must work together in order to replace in vivo eye irritancy testing with appropriately validated in vitro methods.",
author = "Alan Goldberg and Silber, {P. M.}",
year = "1992",
language = "English (US)",
volume = "9",
pages = "161--192",
journal = "Lens and Eye Toxicity Research",
issn = "1042-6922",
publisher = "Marcel Dekker Inc.",
number = "3-4",

}

TY - JOUR

T1 - Status of in vitro ocular irritation testing

AU - Goldberg, Alan

AU - Silber, P. M.

PY - 1992

Y1 - 1992

N2 - This paper reviews advances in the validation of alternative methods for eye irritation testing since the 1987 publication, A Critical Evaluation of Alternatives to Acute Ocular Irritation Testing (1). We have highlighted details of methods that appear promising and identified the minimum needs and endpoints necessary to develop a battery or batteries of in vitro tests to evaluate eye irritancy. We have recommended a series of workshops to provide identified batteries for specific classes of chemicals or for specific uses of eye irritancy testing. We have also identified the need for consensus meetings and peer-reviewed publication to ensure that the most predictive batteries become parts of validation studies. Finally, we note that academic scientists, industry, government and the animal protection community must work together in order to replace in vivo eye irritancy testing with appropriately validated in vitro methods.

AB - This paper reviews advances in the validation of alternative methods for eye irritation testing since the 1987 publication, A Critical Evaluation of Alternatives to Acute Ocular Irritation Testing (1). We have highlighted details of methods that appear promising and identified the minimum needs and endpoints necessary to develop a battery or batteries of in vitro tests to evaluate eye irritancy. We have recommended a series of workshops to provide identified batteries for specific classes of chemicals or for specific uses of eye irritancy testing. We have also identified the need for consensus meetings and peer-reviewed publication to ensure that the most predictive batteries become parts of validation studies. Finally, we note that academic scientists, industry, government and the animal protection community must work together in order to replace in vivo eye irritancy testing with appropriately validated in vitro methods.

UR - http://www.scopus.com/inward/record.url?scp=0027058404&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027058404&partnerID=8YFLogxK

M3 - Article

C2 - 1301780

AN - SCOPUS:0027058404

VL - 9

SP - 161

EP - 192

JO - Lens and Eye Toxicity Research

JF - Lens and Eye Toxicity Research

SN - 1042-6922

IS - 3-4

ER -