Status of HBsAg seroprevalence in 15 million rural couples in China: A cross-sectional study

Long Zhang, Yuan Yuan Wang, Yan Jie Huang, Qiao Mei Wang, Kenrad E. Nelson, An Qi Wang, Hai Ping Shen, Xiao Li Liu, Yi Ping Zhang, Dong Hai Yan, Zuo Qi Peng, Hong Guang Zhang, Ya Zhang, Jun Zhao, Yan Wang, Ying Yang, Yuan He, Ji Hong Xu, Du Jia Liu, Tong Jun GuoXiao Na Xin, Hong Zhou, Xu Ma

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Abstract

A cross-sectional analysis of prevalence of hepatitis B virus infection (HBV) among rural couples was conducted between 2010 and 2014. Serologic HBV markers, including hepatitis B surface antigen (HBsAg) and e antigen (HBeAg), were tested. Primary outcome of interest comprised HBsAg positivity in couples (both positive: F+M+, only wife positive: F+M-, only husband positive: F-M+), and secondary outcome consisted of prevalence and risk factors of HBsAg positivity among husbands or wives. Of 14,816,300 couples included, 0.7% were F+M+; 6.3% were F-M+; 4.4% were F+M-, resulting in the overall seroprevalence of 11.4%. Individually, 6.1% were HBsAg positive with a higher rate seen in husbands (7.0%) than in wives (5.2%). Wife's HBeAg(+)/HBsAg (+) (AOR = 2.61), HBeAg(-)/HBsAg (+) (AOR = 2.23), positivity of syphilis (AOR = 1.50), living in a high-risk region (AOR = 1.46) were significantly predictors of HBsAg positivity in husbands. Prevalence and predictors of HBsAg positivity in wives had similar results. Our data show a high burden and discordant pattern of HBV infection in rural couples, and partner's double positivity of HBeAg and HBsAg was the most significant factor of HBV infection in couples. A comprehensive strategy that emphasizes vaccination and education is needed.

Original languageEnglish (US)
Article number42822
JournalScientific reports
Volume7
DOIs
StatePublished - Feb 21 2017

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    Zhang, L., Wang, Y. Y., Huang, Y. J., Wang, Q. M., Nelson, K. E., Wang, A. Q., Shen, H. P., Liu, X. L., Zhang, Y. P., Yan, D. H., Peng, Z. Q., Zhang, H. G., Zhang, Y., Zhao, J., Wang, Y., Yang, Y., He, Y., Xu, J. H., Liu, D. J., ... Ma, X. (2017). Status of HBsAg seroprevalence in 15 million rural couples in China: A cross-sectional study. Scientific reports, 7, [42822]. https://doi.org/10.1038/srep42822