Statistical prediction of the optimal site for thalamotomy in parkinsonian tremor

Frederick Lenz, S. L. Normand, H. C. Kwan, D. Andrews, L. H. Rowland, M. W. Jones, M. Seike, Y. C. Lin, R. R. Tasker, J. O. Dostrovsky, Y. E. Lenz

Research output: Contribution to journalArticle

Abstract

Stereotactic lesions in the thalamus for treatment of parkinsonian tremor are often made at the location where neurons fire at approximately tremor frequency (tremor cells). Some of these cells show a large amount of activity at tremor frequency and are significantly correlated with electromyographic activity (EMG) during tremor. Our analysis of cellular location identifies a cluster of neurons showing activity characterized both by concentration of power at tremor frequency and by significant correlation with EMG. In a retrospective analysis of results in 15 patients, lesions placed within 2 mm of the center of this cluster were uniformly effective in relieving tremor. Therefore, a small lesion targeting this cluster is effective in treatment of parkinsonian tremor.

Original languageEnglish (US)
Pages (from-to)318-328
Number of pages11
JournalMovement disorders : official journal of the Movement Disorder Society
Volume10
Issue number3
DOIs
StatePublished - 1995

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Tremor
Neurons
Thalamus
Therapeutics

Keywords

  • Coherence
  • Parkinson's disease
  • Spectral cross-correlation analysis
  • Tremor

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Statistical prediction of the optimal site for thalamotomy in parkinsonian tremor. / Lenz, Frederick; Normand, S. L.; Kwan, H. C.; Andrews, D.; Rowland, L. H.; Jones, M. W.; Seike, M.; Lin, Y. C.; Tasker, R. R.; Dostrovsky, J. O.; Lenz, Y. E.

In: Movement disorders : official journal of the Movement Disorder Society, Vol. 10, No. 3, 1995, p. 318-328.

Research output: Contribution to journalArticle

Lenz, F, Normand, SL, Kwan, HC, Andrews, D, Rowland, LH, Jones, MW, Seike, M, Lin, YC, Tasker, RR, Dostrovsky, JO & Lenz, YE 1995, 'Statistical prediction of the optimal site for thalamotomy in parkinsonian tremor', Movement disorders : official journal of the Movement Disorder Society, vol. 10, no. 3, pp. 318-328. https://doi.org/10.1002/mds.870100315
Lenz, Frederick ; Normand, S. L. ; Kwan, H. C. ; Andrews, D. ; Rowland, L. H. ; Jones, M. W. ; Seike, M. ; Lin, Y. C. ; Tasker, R. R. ; Dostrovsky, J. O. ; Lenz, Y. E. / Statistical prediction of the optimal site for thalamotomy in parkinsonian tremor. In: Movement disorders : official journal of the Movement Disorder Society. 1995 ; Vol. 10, No. 3. pp. 318-328.
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AU - Rowland, L. H.

AU - Jones, M. W.

AU - Seike, M.

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AU - Tasker, R. R.

AU - Dostrovsky, J. O.

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