Statistical normalization techniques for magnetic resonance imaging

Russell T. Shinohara, Elizabeth M. Sweeney, Jeff Goldsmith, Navid Shiee, Farrah J. Mateen, Peter A. Calabresi, Samson Jarso, Dzung Pham, Daniel Salo Reich, Ciprian M. Crainiceanu

Research output: Contribution to journalArticlepeer-review


While computed tomography and other imaging techniques are measured in absolute units with physical meaning, magnetic resonance images are expressed in arbitrary units that are difficult to interpret and differ between study visits and subjects. Much work in the image processing literature on intensity normalization has focused on histogram matching and other histogram mapping techniques, with little emphasis on normalizing images to have biologically interpretable units. Furthermore, there are no formalized principles or goals for the crucial comparability of image intensities within and across subjects. To address this, we propose a set of criteria necessary for the normalization of images. We further propose simple and robust biologically motivated normalization techniques for multisequence brain imaging that have the same interpretation across acquisitions and satisfy the proposed criteria. We compare the performance of different normalization methods in thousands of images of patients with Alzheimer's disease, hundreds of patients with multiple sclerosis, and hundreds of healthy subjects obtained in several different studies at dozens of imaging centers.

Original languageEnglish (US)
Pages (from-to)9-19
Number of pages11
JournalNeuroImage: Clinical
StatePublished - 2014


  • Image analysis
  • Magnetic resonance imaging
  • Normalization
  • Statistics

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology
  • Cognitive Neuroscience


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