Statistical modeling of Agatston score in multi-ethnic study of atherosclerosis (MESA)

Shuangge Ma, Anna Liu, Jeffrey Carr, Wendy S Post, Richard Kronmal

Research output: Contribution to journalArticle

Abstract

The MESA (Multi-Ethnic Study of Atherosclerosis) is an ongoing study of the prevalence, risk factors, and progression of subclinical cardiovascular disease in a multi-ethnic cohort. It provides a valuable opportunity to examine the development and progression of CAC (coronary artery calcium), which is an important risk factor for the development of coronary heart disease. In MESA, about half of the CAC scores are zero and the rest are continuously distributed. Such data has been referred to as "zero-inflated data" and may be described using two-part models. Existing two-part model studies have limitations in that they usually consider parametric models only, make the assumption of known forms of the covariate effects, and focus only on the estimation property of the models. In this article, we investigate statistical modeling of CAC in MESA. Building on existing studies, we focus on two-part models. We investigate both parametric and semiparametric, and both proportional and nonproportional models. For various models, we study their estimation as well as prediction properties. We show that, to fully describe the relationship between covariates and CAC development, the semiparametric model with nonproportional covariate effects is needed. In contrast, for the purpose of prediction, the parametric model with proportional covariate effects is sufficient. This study provides a statistical basis for describing the behaviors of CAC and insights into its biological mechanisms.

Original languageEnglish (US)
Article numbere12036
JournalPLoS One
Volume5
Issue number8
DOIs
StatePublished - 2010

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atherosclerosis
Atherosclerosis
Coronary Vessels
Calcium
coronary vessels
calcium
Coronary Disease
Cardiovascular Diseases
risk factors
Cross-Sectional Studies
prediction
cardiovascular diseases

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Statistical modeling of Agatston score in multi-ethnic study of atherosclerosis (MESA). / Ma, Shuangge; Liu, Anna; Carr, Jeffrey; Post, Wendy S; Kronmal, Richard.

In: PLoS One, Vol. 5, No. 8, e12036, 2010.

Research output: Contribution to journalArticle

Ma, Shuangge ; Liu, Anna ; Carr, Jeffrey ; Post, Wendy S ; Kronmal, Richard. / Statistical modeling of Agatston score in multi-ethnic study of atherosclerosis (MESA). In: PLoS One. 2010 ; Vol. 5, No. 8.
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