Statistical inference for the area under the receiver operating characteristic curve in the presence of random measurement error

Enrique F. Schisterman, David Faraggi, Benjamin Reiser, Maurizio Trevisan

Research output: Contribution to journalArticle

Abstract

The area under the receiver operating characteristic curve is the most commonly used measure of the ability of a biomarker to distinguish between two populations. Some markers are subject to substantial measurement error. Under normality assumptions, the authors develop a confidence interval procedure for the area under the receiver operating characteristic curve that adjusts for measurement error. This procedure assumes the availability of data from a reliability study of the biomarker. A simulation study was used to check the validity of the proposed confidence interval. Furthermore, it was shown that not adjusting for measurement error could result in a serious understatement of the effectiveness of the biomarker.

Original languageEnglish (US)
Pages (from-to)174-179
Number of pages6
JournalAmerican Journal of Epidemiology
Volume154
Issue number2
DOIs
StatePublished - Jul 15 2001
Externally publishedYes

Keywords

  • Cardiovascular diseases
  • Reliability
  • Repeated measures
  • Thiobarbituric acid reaction substances

ASJC Scopus subject areas

  • Epidemiology

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