Statistical Considerations in Analysis and Interpretation of Biomarker Studies

C. R. Parikh; H. Thiessen Philbrook

doi:10.1016/B978-0-12-803014-1.00002-9

Statistical Considerations in Analysis and Interpretation of Biomarker Studies

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Here we discuss traditional and emerging statistical methods for evaluating the prediction performance of biomarkers. We highlight considerations for planning a study and discuss unique statistical considerations when executing studies assessing biomarker performance including appropriate metrics to quantify biomarker-prediction performance and sample-size estimation.

Original language	English (US)
Title of host publication	Biomarkers of Kidney Disease
Publisher	Elsevier Inc.
Pages	21-32
Number of pages	12
ISBN (Print)	9780128030141
DOIs	https://doi.org/10.1016/B978-0-12-803014-1.00002-9
State	Published - Jan 1 2017
Externally published	Yes

Keywords

Accuracy
False positive rate
Incremental value
ROC curves
True positive rate

ASJC Scopus subject areas

General Medicine

Access to Document

10.1016/B978-0-12-803014-1.00002-9

Cite this

@inbook{a5f2de7c6b0f4d988d98baa48fb85083,

title = "Statistical Considerations in Analysis and Interpretation of Biomarker Studies",

abstract = "Here we discuss traditional and emerging statistical methods for evaluating the prediction performance of biomarkers. We highlight considerations for planning a study and discuss unique statistical considerations when executing studies assessing biomarker performance including appropriate metrics to quantify biomarker-prediction performance and sample-size estimation.",

keywords = "Accuracy, False positive rate, Incremental value, ROC curves, True positive rate",

author = "Parikh, {C. R.} and {Thiessen Philbrook}, H.",

year = "2017",

month = jan,

day = "1",

doi = "10.1016/B978-0-12-803014-1.00002-9",

language = "English (US)",

isbn = "9780128030141",

pages = "21--32",

booktitle = "Biomarkers of Kidney Disease",

publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Statistical Considerations in Analysis and Interpretation of Biomarker Studies

AU - Parikh, C. R.

AU - Thiessen Philbrook, H.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Here we discuss traditional and emerging statistical methods for evaluating the prediction performance of biomarkers. We highlight considerations for planning a study and discuss unique statistical considerations when executing studies assessing biomarker performance including appropriate metrics to quantify biomarker-prediction performance and sample-size estimation.

AB - Here we discuss traditional and emerging statistical methods for evaluating the prediction performance of biomarkers. We highlight considerations for planning a study and discuss unique statistical considerations when executing studies assessing biomarker performance including appropriate metrics to quantify biomarker-prediction performance and sample-size estimation.

KW - Accuracy

KW - False positive rate

KW - Incremental value

KW - ROC curves

KW - True positive rate

UR - http://www.scopus.com/inward/record.url?scp=85010204588&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85010204588&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-803014-1.00002-9

DO - 10.1016/B978-0-12-803014-1.00002-9

M3 - Chapter

AN - SCOPUS:85010204588

SN - 9780128030141

SP - 21

EP - 32

BT - Biomarkers of Kidney Disease

PB - Elsevier Inc.

ER -

Statistical Considerations in Analysis and Interpretation of Biomarker Studies

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this