Statin use associates with a lower incidence of acute kidney injury after major elective surgery

Amber O. Molnar, Steven G. Coca, Phillip J. Devereaux, Arsh K. Jain, Abhijat Kitchlu, Jin Luo, Chirag Parikh, J. Michael Paterson, Nausheen Siddiqui, Ron Wald, Michael Walsh, Amit X. Garg

Research output: Contribution to journalArticle

Abstract

Statins abrogate ischemic renal injury in animal studies but whether they are renoprotective in humans is unknown. We conducted a population-based retrospective cohort study that included 213,347 older patients who underwent major elective surgery in the province of Ontario, Canada from 1995 to 2008. During the first 14 postoperative days, 1.9% (4020 patients), developed acute kidney injury and 0.5% (1173 patients), required acute dialysis. The 30-day mortality rate was 2.8% (5974 patients). Prior to surgery, 32% of patients were taking a statin. After statistical adjustment for patient and surgical characteristics, statin use associated with 16% lower odds of acute kidney injury (OR, 0.84; 95% CI, 0.79 to 0.90), 17% lower odds of acute dialysis (OR, 0.83; 95% CI, 0.72 to 0.95), and 21% lower odds of mortality (OR, 0.79; 95% CI, 0.74 to 0.85). Propensity score matching produced similar results. These data suggest that statins may protect against renal complications after major elective surgery and reduce perioperative mortality.

Original languageEnglish (US)
Pages (from-to)939-946
Number of pages8
JournalJournal of the American Society of Nephrology
Volume22
Issue number5
DOIs
StatePublished - May 1 2011

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Hydroxymethylglutaryl-CoA Reductase Inhibitors
Acute Kidney Injury
Incidence
Mortality
Dialysis
Kidney
Propensity Score
Ontario
Canada
Cohort Studies
Retrospective Studies
Wounds and Injuries
Population

ASJC Scopus subject areas

  • Nephrology

Cite this

Molnar, A. O., Coca, S. G., Devereaux, P. J., Jain, A. K., Kitchlu, A., Luo, J., ... Garg, A. X. (2011). Statin use associates with a lower incidence of acute kidney injury after major elective surgery. Journal of the American Society of Nephrology, 22(5), 939-946. https://doi.org/10.1681/ASN.2010050442

Statin use associates with a lower incidence of acute kidney injury after major elective surgery. / Molnar, Amber O.; Coca, Steven G.; Devereaux, Phillip J.; Jain, Arsh K.; Kitchlu, Abhijat; Luo, Jin; Parikh, Chirag; Michael Paterson, J.; Siddiqui, Nausheen; Wald, Ron; Walsh, Michael; Garg, Amit X.

In: Journal of the American Society of Nephrology, Vol. 22, No. 5, 01.05.2011, p. 939-946.

Research output: Contribution to journalArticle

Molnar, AO, Coca, SG, Devereaux, PJ, Jain, AK, Kitchlu, A, Luo, J, Parikh, C, Michael Paterson, J, Siddiqui, N, Wald, R, Walsh, M & Garg, AX 2011, 'Statin use associates with a lower incidence of acute kidney injury after major elective surgery', Journal of the American Society of Nephrology, vol. 22, no. 5, pp. 939-946. https://doi.org/10.1681/ASN.2010050442
Molnar, Amber O. ; Coca, Steven G. ; Devereaux, Phillip J. ; Jain, Arsh K. ; Kitchlu, Abhijat ; Luo, Jin ; Parikh, Chirag ; Michael Paterson, J. ; Siddiqui, Nausheen ; Wald, Ron ; Walsh, Michael ; Garg, Amit X. / Statin use associates with a lower incidence of acute kidney injury after major elective surgery. In: Journal of the American Society of Nephrology. 2011 ; Vol. 22, No. 5. pp. 939-946.
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