Statin use and decline in gait speed in community-dwelling older adults

Wei Hsuan Lo-Ciganic, Subashan Perera, Shelly L. Gray, Robert M. Boudreau, Janice C. Zgibor, Elsa S. Strotmeyer, Julie M. Donohue, Clareann H. Bunker, Anne B. Newman, Eleanor Marie Simonsick, Douglas C. Bauer, Suzanne Satterfield, Paolo Caserotti, Tamara Harris, Ronald I. Shorr, Joseph T. Hanlon

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: To examine the association between statin use and objectively assessed decline in gait speed in community-dwelling older adults. DESIGN: Longitudinal cohort study. SETTING: Health, Aging and Body Composition (Health ABC) Study. PARTICIPANTS: Two thousand five participants aged 70-79 at baseline with medication and gait speed data at 1998-99, 1999-2000, 2001-02, and 2002-03. MEASUREMENTS: The independent variables were any statin use and their standardized daily doses (low, moderate, high) and lipophilicity. The primary outcome measure was decline in gait speed of 0.1 m/s or more in the following year of statin use. Multivariable generalized estimating equations were used, adjusting for demographic characteristics, health-related behaviors, health status, and access to health care. RESULTS: Statin use increased from 16.2% in 1998-99 to 25.6% in 2002-03. The overall proportions of those with decline in gait speed of 0.1 m/s or more increased from 22.2% in 1998 to 23.9% in 2003. Statin use was not associated with decline in gait speed of 0.1 m/s or more (adjusted odds ratio (AOR) = 0.90, 95% confidence interval (CI) = 0.77-1.06). Similar nonsignificant trends were also seen with the use of hydrophilic or lipophilic statins. Users of low-dose statins were found to have a 22% lower risk of decline in gait speed than nonusers (AOR = 0.78, 95% CI = 0.61-0.99), which was mainly driven by the results from 1999-2000 follow-up. CONCLUSION: These results suggest that statin use did not increase decline in gait speed in community-dwelling older adults.

Original languageEnglish (US)
Pages (from-to)124-129
Number of pages6
JournalJournal of the American Geriatrics Society
Volume63
Issue number1
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

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Independent Living
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Odds Ratio
Confidence Intervals
Health Services Accessibility
Walking Speed
Health
Body Composition
Health Status
Longitudinal Studies
Cohort Studies
Demography
Outcome Assessment (Health Care)

Keywords

  • Aged
  • Gait speed
  • Hydroxymethylglutaryl-CoA reductase inhibitors
  • Physical function
  • Statins

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Lo-Ciganic, W. H., Perera, S., Gray, S. L., Boudreau, R. M., Zgibor, J. C., Strotmeyer, E. S., ... Hanlon, J. T. (2015). Statin use and decline in gait speed in community-dwelling older adults. Journal of the American Geriatrics Society, 63(1), 124-129. https://doi.org/10.1111/jgs.13134

Statin use and decline in gait speed in community-dwelling older adults. / Lo-Ciganic, Wei Hsuan; Perera, Subashan; Gray, Shelly L.; Boudreau, Robert M.; Zgibor, Janice C.; Strotmeyer, Elsa S.; Donohue, Julie M.; Bunker, Clareann H.; Newman, Anne B.; Simonsick, Eleanor Marie; Bauer, Douglas C.; Satterfield, Suzanne; Caserotti, Paolo; Harris, Tamara; Shorr, Ronald I.; Hanlon, Joseph T.

In: Journal of the American Geriatrics Society, Vol. 63, No. 1, 01.01.2015, p. 124-129.

Research output: Contribution to journalArticle

Lo-Ciganic, WH, Perera, S, Gray, SL, Boudreau, RM, Zgibor, JC, Strotmeyer, ES, Donohue, JM, Bunker, CH, Newman, AB, Simonsick, EM, Bauer, DC, Satterfield, S, Caserotti, P, Harris, T, Shorr, RI & Hanlon, JT 2015, 'Statin use and decline in gait speed in community-dwelling older adults', Journal of the American Geriatrics Society, vol. 63, no. 1, pp. 124-129. https://doi.org/10.1111/jgs.13134
Lo-Ciganic WH, Perera S, Gray SL, Boudreau RM, Zgibor JC, Strotmeyer ES et al. Statin use and decline in gait speed in community-dwelling older adults. Journal of the American Geriatrics Society. 2015 Jan 1;63(1):124-129. https://doi.org/10.1111/jgs.13134
Lo-Ciganic, Wei Hsuan ; Perera, Subashan ; Gray, Shelly L. ; Boudreau, Robert M. ; Zgibor, Janice C. ; Strotmeyer, Elsa S. ; Donohue, Julie M. ; Bunker, Clareann H. ; Newman, Anne B. ; Simonsick, Eleanor Marie ; Bauer, Douglas C. ; Satterfield, Suzanne ; Caserotti, Paolo ; Harris, Tamara ; Shorr, Ronald I. ; Hanlon, Joseph T. / Statin use and decline in gait speed in community-dwelling older adults. In: Journal of the American Geriatrics Society. 2015 ; Vol. 63, No. 1. pp. 124-129.
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abstract = "OBJECTIVES: To examine the association between statin use and objectively assessed decline in gait speed in community-dwelling older adults. DESIGN: Longitudinal cohort study. SETTING: Health, Aging and Body Composition (Health ABC) Study. PARTICIPANTS: Two thousand five participants aged 70-79 at baseline with medication and gait speed data at 1998-99, 1999-2000, 2001-02, and 2002-03. MEASUREMENTS: The independent variables were any statin use and their standardized daily doses (low, moderate, high) and lipophilicity. The primary outcome measure was decline in gait speed of 0.1 m/s or more in the following year of statin use. Multivariable generalized estimating equations were used, adjusting for demographic characteristics, health-related behaviors, health status, and access to health care. RESULTS: Statin use increased from 16.2{\%} in 1998-99 to 25.6{\%} in 2002-03. The overall proportions of those with decline in gait speed of 0.1 m/s or more increased from 22.2{\%} in 1998 to 23.9{\%} in 2003. Statin use was not associated with decline in gait speed of 0.1 m/s or more (adjusted odds ratio (AOR) = 0.90, 95{\%} confidence interval (CI) = 0.77-1.06). Similar nonsignificant trends were also seen with the use of hydrophilic or lipophilic statins. Users of low-dose statins were found to have a 22{\%} lower risk of decline in gait speed than nonusers (AOR = 0.78, 95{\%} CI = 0.61-0.99), which was mainly driven by the results from 1999-2000 follow-up. CONCLUSION: These results suggest that statin use did not increase decline in gait speed in community-dwelling older adults.",
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AU - Lo-Ciganic, Wei Hsuan

AU - Perera, Subashan

AU - Gray, Shelly L.

AU - Boudreau, Robert M.

AU - Zgibor, Janice C.

AU - Strotmeyer, Elsa S.

AU - Donohue, Julie M.

AU - Bunker, Clareann H.

AU - Newman, Anne B.

AU - Simonsick, Eleanor Marie

AU - Bauer, Douglas C.

AU - Satterfield, Suzanne

AU - Caserotti, Paolo

AU - Harris, Tamara

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N2 - OBJECTIVES: To examine the association between statin use and objectively assessed decline in gait speed in community-dwelling older adults. DESIGN: Longitudinal cohort study. SETTING: Health, Aging and Body Composition (Health ABC) Study. PARTICIPANTS: Two thousand five participants aged 70-79 at baseline with medication and gait speed data at 1998-99, 1999-2000, 2001-02, and 2002-03. MEASUREMENTS: The independent variables were any statin use and their standardized daily doses (low, moderate, high) and lipophilicity. The primary outcome measure was decline in gait speed of 0.1 m/s or more in the following year of statin use. Multivariable generalized estimating equations were used, adjusting for demographic characteristics, health-related behaviors, health status, and access to health care. RESULTS: Statin use increased from 16.2% in 1998-99 to 25.6% in 2002-03. The overall proportions of those with decline in gait speed of 0.1 m/s or more increased from 22.2% in 1998 to 23.9% in 2003. Statin use was not associated with decline in gait speed of 0.1 m/s or more (adjusted odds ratio (AOR) = 0.90, 95% confidence interval (CI) = 0.77-1.06). Similar nonsignificant trends were also seen with the use of hydrophilic or lipophilic statins. Users of low-dose statins were found to have a 22% lower risk of decline in gait speed than nonusers (AOR = 0.78, 95% CI = 0.61-0.99), which was mainly driven by the results from 1999-2000 follow-up. CONCLUSION: These results suggest that statin use did not increase decline in gait speed in community-dwelling older adults.

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