Statin therapy in athletes and patients performing regular intense exercise – Position paper from the International Lipid Expert Panel (ILEP)

Niki Katsiki, Dimitri P. Mikhailidis, Gani Bajraktari, Gani Bajraktari, Gani Bajraktari, Andre R. Miserez, Andre R. Miserez, Arrigo F.G. Cicero, Eric Bruckert, Maria Corina Serban, Erkin Mirrakhimov, Fahad Alnouri, Željko Reiner, György Paragh, Amirhossein Sahebkar, Amirhossein Sahebkar, Amirhossein Sahebkar, Maciej Banach, Maciej Banach, Maciej BanachFahad Alnouri, Fahma Amar, Atanas G. Atanasov, Gani Bajraktari, Maciej Banach, Marcin A. Bartlomiejczyk, Bojko Bjelakovic, Eric Bruckert, Agata Bielecka-Dabrowa, Alberto Cafferata, Richard Ceska, Arrigo F.G. Cicero, Xavier Collet, Olivier Descamps, Nair Devaki, Dragan Djuric, Ronen Durst, Marat V. Ezhov, Zlatko Fras, Dan Gaita, Stephan von Haehling, Adrian V. Hernandez, Steven R. Jones, Jacek Jozwiak, Nona Kakauridze, Niki Katsiki, Amit Khera, Karam Kostner, Raimondas Kubilius, Gustavs Latkovskis, G. B.John Mancini, A. David Marais, Seth S. Martin, Julio Acosta Martinez, Mohsen Mazidi, Dimitri P. Mikhailidis, Erkin Mirrakhimov, Andre R. Miserez, Olena Mitchenko, Patrick Moriarty, Seyed Mohammad Nabavi, Demosthenes B. Panagiotakos, György Paragh, Daniel Pella, Peter E. Penson, Zaneta Petrulioniene, Matteo Pirro, Arman Postadzhiyan, Raman Puri, Ashraf Reda, Željko Reiner, Jemaa Riadh, Dimitri Richter, Manfredi Rizzo, Massimiliano Ruscica, Amirhossein Sahebkar, Naveed Sattar, Maria Corina Serban, Abdulla M.A. Shehab, Aleksandr B. Shek, Cesare R. Sirtori, Claudia Stefanutti, Tomasz Tomasik, Peter P. Toth, Margus Viigimaa, Dragos Vinereanu, Branislav Vohnout, Michal Vrablik, Nathan D. Wong, Hung I. Yeh, Jiang Zhisheng, Andreas Zirlik

Research output: Contribution to journalReview article

Abstract

Acute and chronic physical exercises may enhance the development of statin-related myopathy. In this context, the recent (2019) guidelines of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS) for the management of dyslipidemias recommend that, although individuals with dyslipidemia should be advised to engage in regular moderate physical exercise (for at least 30 min daily), physicians should be alerted with regard to myopathy and creatine kinase (CK) elevation in statin-treated sport athletes. However it is worth emphasizing that abovementioned guidelines, previous and recent ESC/EAS consensus papers on adverse effects of statin therapy as well as other previous attempts on this issue, including the ones from the International Lipid Expert Panel (ILEP), give only general recommendations on how to manage patients requiring statin therapy on regular exercises. Therefore, these guidelines in the form of the Position Paper are the first such an attempt to summary existing, often scarce knowledge, and to present this important issue in the form of step-by-step practical recommendations. It is critically important as we might observe more and more individuals on regular exercises/athletes requiring statin therapy due to their cardiovascular risk.

Original languageEnglish (US)
Article number104719
JournalPharmacological Research
Volume155
DOIs
StatePublished - May 2020

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Keywords

  • Athleths
  • Exercises
  • Management
  • Mylagia
  • Statin intolerance

ASJC Scopus subject areas

  • Pharmacology

Cite this

Katsiki, N., Mikhailidis, D. P., Bajraktari, G., Bajraktari, G., Bajraktari, G., Miserez, A. R., Miserez, A. R., Cicero, A. F. G., Bruckert, E., Serban, M. C., Mirrakhimov, E., Alnouri, F., Reiner, Ž., Paragh, G., Sahebkar, A., Sahebkar, A., Sahebkar, A., Banach, M., Banach, M., ... Zirlik, A. (2020). Statin therapy in athletes and patients performing regular intense exercise – Position paper from the International Lipid Expert Panel (ILEP). Pharmacological Research, 155, [104719]. https://doi.org/10.1016/j.phrs.2020.104719