Statin therapy and inflammation in patients with diabetes treated with high dose aspirin

Rahul Chaudhary, Kevin P. Bliden, Jalaj Garg, Nafees Mohammed, Udaya Tantry, Denny Mathew, Peter P. Toth, Christopher Franzese, Martin Gesheff, Shachi Pandya, Paul Gurbel

Research output: Contribution to journalArticlepeer-review

Abstract

Background Statin and aspirin form the therapeutic cornerstone in patients with coronary artery disease (CAD) and diabetes. Little is known about relationship of statins with blood thrombogenicity and inflammation in these patients. Methods Two hundred nine consecutive patients with diabetes and suspected CAD undergoing elective cardiac catheterization were divided in groups based on statin treatment in the Multi-Analyte, Thrombogenic, and Genetic Markers Atherosclerosis study. Urinary 11-dehydrothromboxane B2 (11-dh-TxB2), lipid profile and oxLDL/β2GPI were measured by AspirinWorks™ ELISA assay, vertical density gradient ultracentrifugation and immunoassay respectively. Thrombelastography, and ADP- and collagen-induced light transmittance aggregometry assessed thrombogenicity. CAD was classified as none/minor [< 20% diameter stenosis (DS)], moderate (20–75% DS), or severe (> 75% DS). Results Severe, moderate, and no CAD was observed in 66, 19, and 15% of patients respectively. Patients on statins had significantly lower 11-dh-TxB2, collagen-induced aggregation, total cholesterol, total LDL, LDL3, oxidized-LDL, Apo B100, and ApoB100/A1 ratio (p < 0.01 for all). Statin therapy demonstrated a lower proportion of patients with high urinary 11-dh-TxB2 (> 1500 pg 11-dh-TxB2/mg creatinine) (25 vs. 57%, p = 0.01). Conclusion Statins along with aspirin, confers additional anti-inflammatory and antithrombotic effect in diabetics with CAD. Urinary 11-dh-TxB2 may be a useful biomarker for personalizing statin therapy.

Original languageEnglish (US)
Pages (from-to)1365-1370
Number of pages6
JournalJournal of Diabetes and its Complications
Volume30
Issue number7
DOIs
StatePublished - Sep 1 2016

Keywords

  • 11-Dehydrothromboxane B2
  • CAD
  • Diabetes
  • Inflammation
  • Statin

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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