Statin therapy and inflammation in patients with diabetes treated with high dose aspirin

Rahul Chaudhary, Kevin P. Bliden, Jalaj Garg, Nafees Mohammed, Udaya Tantry, Denny Mathew, Peter P. Toth, Christopher Franzese, Martin Gesheff, Shachi Pandya, Paul Gurbel

Research output: Contribution to journalArticle

Abstract

Background: Statin and aspirin form the therapeutic cornerstone in patients with coronary artery disease (CAD) and diabetes. Little is known about relationship of statins with blood thrombogenicity and inflammation in these patients. Methods: Two hundred nine consecutive patients with diabetes and suspected CAD undergoing elective cardiac catheterization were divided in groups based on statin treatment in the Multi-Analyte, Thrombogenic, and Genetic Markers Atherosclerosis study. Urinary 11-dehydrothromboxane B2 (11-dh-TxB2), lipid profile and oxLDL/β2GPI were measured by AspirinWorks™ ELISA assay, vertical density gradient ultracentrifugation and immunoassay respectively. Thrombelastography, and ADP- and collagen-induced light transmittance aggregometry assessed thrombogenicity. CAD was classified as none/minor [. 75% DS). Results: Severe, moderate, and no CAD was observed in 66, 19, and 15% of patients respectively. Patients on statins had significantly lower 11-dh-TxB2, collagen-induced aggregation, total cholesterol, total LDL, LDL3, oxidized-LDL, Apo B100, and ApoB100/A1 ratio (p . 1500. pg 11-dh-TxB2/mg creatinine) (25 vs. 57%, p = 0.01). Conclusion: Statins along with aspirin, confers additional anti-inflammatory and antithrombotic effect in diabetics with CAD. Urinary 11-dh-TxB2 may be a useful biomarker for personalizing statin therapy.

Original languageEnglish (US)
JournalJournal of Diabetes and its Complications
DOIs
StateAccepted/In press - Mar 3 2016

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Keywords

  • 11-Dehydrothromboxane B2
  • CAD
  • Diabetes
  • Inflammation
  • Statin

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Chaudhary, R., Bliden, K. P., Garg, J., Mohammed, N., Tantry, U., Mathew, D., Toth, P. P., Franzese, C., Gesheff, M., Pandya, S., & Gurbel, P. (Accepted/In press). Statin therapy and inflammation in patients with diabetes treated with high dose aspirin. Journal of Diabetes and its Complications. https://doi.org/10.1016/j.jdiacomp.2016.05.002