Abstract
Background - Statin therapy reduces adverse outcomes, with a minimal decrease in vessel stenosis. Magnetic resonance imaging (MRI) noninvasively detects atherosclerotic plaque (AP) reduction. We hypothesized that statin-induced AP regression can be monitored by MRI and detected earlier than previously reported and is significantly associated with its lipid-lowering effect. Methods and Results - APs in thoracic aorta were measured by combined surface/transesophageal MRI in 27 patients (treated with simvastatin 20 to 80 mg daily) before and after 6 months of therapy. AP volume and luminal dimensions were measured from 6 cross sections used to construct a 2.4-cm 3D volume of the aorta that included plaque and lumen. Method reproducibility was studied in 10 patients imaged twice, 1 week apart. AP volume was reduced from 3.3±1.4 to 2.9±1.4 cm3 at 6 months (P3, P]
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2336-2341 |
| Number of pages | 6 |
| Journal | Circulation |
| Volume | 110 |
| Issue number | 16 |
| DOIs | |
| State | Published - Oct 19 2004 |
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Keywords
- Atherosclerosis
- Lipids
- Magnetic resonance imaging
- Plaque
ASJC Scopus subject areas
- Physiology
- Cardiology and Cardiovascular Medicine
Cite this
Statin-induced cholesterol lowering and plaque regression after 6 months of magnetic resonance imaging-monitored therapy. / Lima, Joao; Desai, Milind Y.; Steen, Henning; Warren, William P.; Gautam, Sandeep; Lai, Shenghan.
In: Circulation, Vol. 110, No. 16, 19.10.2004, p. 2336-2341.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Statin-induced cholesterol lowering and plaque regression after 6 months of magnetic resonance imaging-monitored therapy
AU - Lima, Joao
AU - Desai, Milind Y.
AU - Steen, Henning
AU - Warren, William P.
AU - Gautam, Sandeep
AU - Lai, Shenghan
PY - 2004/10/19
Y1 - 2004/10/19
N2 - Background - Statin therapy reduces adverse outcomes, with a minimal decrease in vessel stenosis. Magnetic resonance imaging (MRI) noninvasively detects atherosclerotic plaque (AP) reduction. We hypothesized that statin-induced AP regression can be monitored by MRI and detected earlier than previously reported and is significantly associated with its lipid-lowering effect. Methods and Results - APs in thoracic aorta were measured by combined surface/transesophageal MRI in 27 patients (treated with simvastatin 20 to 80 mg daily) before and after 6 months of therapy. AP volume and luminal dimensions were measured from 6 cross sections used to construct a 2.4-cm 3D volume of the aorta that included plaque and lumen. Method reproducibility was studied in 10 patients imaged twice, 1 week apart. AP volume was reduced from 3.3±1.4 to 2.9±1.4 cm3 at 6 months (P3, P]
AB - Background - Statin therapy reduces adverse outcomes, with a minimal decrease in vessel stenosis. Magnetic resonance imaging (MRI) noninvasively detects atherosclerotic plaque (AP) reduction. We hypothesized that statin-induced AP regression can be monitored by MRI and detected earlier than previously reported and is significantly associated with its lipid-lowering effect. Methods and Results - APs in thoracic aorta were measured by combined surface/transesophageal MRI in 27 patients (treated with simvastatin 20 to 80 mg daily) before and after 6 months of therapy. AP volume and luminal dimensions were measured from 6 cross sections used to construct a 2.4-cm 3D volume of the aorta that included plaque and lumen. Method reproducibility was studied in 10 patients imaged twice, 1 week apart. AP volume was reduced from 3.3±1.4 to 2.9±1.4 cm3 at 6 months (P3, P]
KW - Atherosclerosis
KW - Lipids
KW - Magnetic resonance imaging
KW - Plaque
UR - http://www.scopus.com/inward/record.url?scp=6444234851&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=6444234851&partnerID=8YFLogxK
U2 - 10.1161/01.CIR.0000145170.22652.51
DO - 10.1161/01.CIR.0000145170.22652.51
M3 - Article
C2 - 15477398
AN - SCOPUS:6444234851
VL - 110
SP - 2336
EP - 2341
JO - Circulation
JF - Circulation
SN - 0009-7322
IS - 16
ER -