Static and dynamic discharge properties of vestibular-nerve afferents in the mouse are affected by core body temperature

Hong Ju Park, David M. Lasker, Lloyd B. Minor

Research output: Contribution to journalArticlepeer-review

Abstract

The goal of this study was to determine the effect of changes in core body temperature on the resting discharge rate and sensitivity of vestibular-nerve afferents. Extracellular recordings were made from vestibular-nerve afferents innervating the semicircular canals in anesthetized C57BL/6 mice maintained at a core body temperature of either 30-32°C (T 31) or 35-37°C (T 36). The resting rates of regular (CV* < 0.1) and irregular afferents (CV* > 0.1) were lower at T 31 than at T 36. Sensitivity and phase were compared for rotations ranging from 0.1 to 12 Hz by calculating coefficients of a transfer function, g \cdot t-{c} s \cdot ( {t-{z} s + 1} )/( {t-{c} s + 1}), for each afferent. The sensitivity (g) increased with CV and with higher core body temperature. The value of the coefficient representing the low-frequency dynamics (t c) varied inversely with CV but did not change with core body temperature. The high-frequency dynamics represented by t z increased with CV and decreased with higher core body temperature. These findings indicate that changes in temperature have effects on the static and dynamic properties of vestibular-nerve afferents.

Original languageEnglish (US)
Pages (from-to)269-275
Number of pages7
JournalExperimental Brain Research
Volume200
Issue number3-4
DOIs
StatePublished - Jan 2010

Keywords

  • Caloric
  • Extracellular
  • Hair cell
  • Irregular
  • Mice
  • Regular
  • VOR

ASJC Scopus subject areas

  • Neuroscience(all)

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