Statement of caution in the interpretation of papillomavirus-associated lesions of the epithelium of uterine cervix

R. Kaufman, L. G. Koss, Robert J Kurman

Research output: Contribution to journalArticle

Abstract

The recent discovery that papillomaviruses are associated with many of the morphologic abnormalities of the squamous epithelium of the uterine cervix previously classified as various forms of cervical intraepithelial neoplasia (dysplasia, carcinoma in situ, CIN) has created a great deal of confusion among pathologists and gynecologists. The facts are as follows: 1. The human papillomavirus-associated lesions (koilocytic atypia, warty atypia, 'flat' or 'inverted' condylomas, subclinical papillomavirus infection) are the most common abnormalities of cervical epithelium in young women but may occur at any age. 2. In a significant proportion of women these lesions have been shown to be associated with other forms of cervical intraepithelial neoplasia and, in some, with invasive carcinoma. 3. At this time, the behavior of papillomavirus-associated lesions cannot be predicted on morphologic grounds, as is also true of other forms of intraepithelial neoplasia. For these reasons, it is the opinion of the undersigned that these lesions should be reported according to the degree of morphologic abnormality, within the framework of the customary reporting system used for precancerous epithelial lesions of the uterine cervix, such as dysplasia, carcinoma in situ, or CIN. The presence of the virus-associated component may be mentioned as a part of the microscopic diagnosis but should not modify the clinical approach to these lesions. Women bearing the virus-associated lesions should receive the same clinical and colposcopic evaluation, treatment, and follow-up as usually administered to women with conventional forms of cervical intraepithelial neoplasia, until more data on the natural history of these lesions are obtained.

Original languageEnglish (US)
Pages (from-to)125
Number of pages1
JournalAmerican Journal of Obstetrics and Gynecology
Volume146
Issue number2
StatePublished - 1983
Externally publishedYes

Fingerprint

Cervix Uteri
Cervical Intraepithelial Neoplasia
Epithelium
Carcinoma in Situ
Confusion
Viral Structures
Asymptomatic Infections
Papillomavirus Infections
Natural History
Viruses
Carcinoma
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

@article{9f505ca91280455c96d4dbdc6ee43372,
title = "Statement of caution in the interpretation of papillomavirus-associated lesions of the epithelium of uterine cervix",
abstract = "The recent discovery that papillomaviruses are associated with many of the morphologic abnormalities of the squamous epithelium of the uterine cervix previously classified as various forms of cervical intraepithelial neoplasia (dysplasia, carcinoma in situ, CIN) has created a great deal of confusion among pathologists and gynecologists. The facts are as follows: 1. The human papillomavirus-associated lesions (koilocytic atypia, warty atypia, 'flat' or 'inverted' condylomas, subclinical papillomavirus infection) are the most common abnormalities of cervical epithelium in young women but may occur at any age. 2. In a significant proportion of women these lesions have been shown to be associated with other forms of cervical intraepithelial neoplasia and, in some, with invasive carcinoma. 3. At this time, the behavior of papillomavirus-associated lesions cannot be predicted on morphologic grounds, as is also true of other forms of intraepithelial neoplasia. For these reasons, it is the opinion of the undersigned that these lesions should be reported according to the degree of morphologic abnormality, within the framework of the customary reporting system used for precancerous epithelial lesions of the uterine cervix, such as dysplasia, carcinoma in situ, or CIN. The presence of the virus-associated component may be mentioned as a part of the microscopic diagnosis but should not modify the clinical approach to these lesions. Women bearing the virus-associated lesions should receive the same clinical and colposcopic evaluation, treatment, and follow-up as usually administered to women with conventional forms of cervical intraepithelial neoplasia, until more data on the natural history of these lesions are obtained.",
author = "R. Kaufman and Koss, {L. G.} and Kurman, {Robert J}",
year = "1983",
language = "English (US)",
volume = "146",
pages = "125",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "2",

}

TY - JOUR

T1 - Statement of caution in the interpretation of papillomavirus-associated lesions of the epithelium of uterine cervix

AU - Kaufman, R.

AU - Koss, L. G.

AU - Kurman, Robert J

PY - 1983

Y1 - 1983

N2 - The recent discovery that papillomaviruses are associated with many of the morphologic abnormalities of the squamous epithelium of the uterine cervix previously classified as various forms of cervical intraepithelial neoplasia (dysplasia, carcinoma in situ, CIN) has created a great deal of confusion among pathologists and gynecologists. The facts are as follows: 1. The human papillomavirus-associated lesions (koilocytic atypia, warty atypia, 'flat' or 'inverted' condylomas, subclinical papillomavirus infection) are the most common abnormalities of cervical epithelium in young women but may occur at any age. 2. In a significant proportion of women these lesions have been shown to be associated with other forms of cervical intraepithelial neoplasia and, in some, with invasive carcinoma. 3. At this time, the behavior of papillomavirus-associated lesions cannot be predicted on morphologic grounds, as is also true of other forms of intraepithelial neoplasia. For these reasons, it is the opinion of the undersigned that these lesions should be reported according to the degree of morphologic abnormality, within the framework of the customary reporting system used for precancerous epithelial lesions of the uterine cervix, such as dysplasia, carcinoma in situ, or CIN. The presence of the virus-associated component may be mentioned as a part of the microscopic diagnosis but should not modify the clinical approach to these lesions. Women bearing the virus-associated lesions should receive the same clinical and colposcopic evaluation, treatment, and follow-up as usually administered to women with conventional forms of cervical intraepithelial neoplasia, until more data on the natural history of these lesions are obtained.

AB - The recent discovery that papillomaviruses are associated with many of the morphologic abnormalities of the squamous epithelium of the uterine cervix previously classified as various forms of cervical intraepithelial neoplasia (dysplasia, carcinoma in situ, CIN) has created a great deal of confusion among pathologists and gynecologists. The facts are as follows: 1. The human papillomavirus-associated lesions (koilocytic atypia, warty atypia, 'flat' or 'inverted' condylomas, subclinical papillomavirus infection) are the most common abnormalities of cervical epithelium in young women but may occur at any age. 2. In a significant proportion of women these lesions have been shown to be associated with other forms of cervical intraepithelial neoplasia and, in some, with invasive carcinoma. 3. At this time, the behavior of papillomavirus-associated lesions cannot be predicted on morphologic grounds, as is also true of other forms of intraepithelial neoplasia. For these reasons, it is the opinion of the undersigned that these lesions should be reported according to the degree of morphologic abnormality, within the framework of the customary reporting system used for precancerous epithelial lesions of the uterine cervix, such as dysplasia, carcinoma in situ, or CIN. The presence of the virus-associated component may be mentioned as a part of the microscopic diagnosis but should not modify the clinical approach to these lesions. Women bearing the virus-associated lesions should receive the same clinical and colposcopic evaluation, treatment, and follow-up as usually administered to women with conventional forms of cervical intraepithelial neoplasia, until more data on the natural history of these lesions are obtained.

UR - http://www.scopus.com/inward/record.url?scp=0020549714&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020549714&partnerID=8YFLogxK

M3 - Article

C2 - 6303127

AN - SCOPUS:0020549714

VL - 146

SP - 125

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 2

ER -