State-of-the-art paper: Therapeutic hypothermia in out of hospital cardiac arrest survivors

Mohi E. Alkadri, Matthew N. Peters, Morgan J. Katz, Christopher J. White

Research output: Contribution to journalArticlepeer-review


Out of hospital cardiac arrest (OHCA) is associated with an extremely poor survival rate, with mortality in most cases being related to neurological injury. Among patients who experience return of spontaneous circulation (ROSC), therapeutic hypothermia (TH) is the only proven intervention shown to reduce mortality and improve neurological outcome. First described in 1958, the field of TH has rapidly evolved in recent years. While recent technological advances in TH will likely improve outcomes in OHCA survivors, several fundamental questions remain to be answered including the optimal speed of cooling, which patients benefit from an early invasive strategy, and whether technological advances will facilitate application of TH in the field. An increased awareness and understanding of TH strategies, devices, monitoring, techniques, and complications will allow for a more widespread adoption of this important treatment modality.

Original languageEnglish (US)
Pages (from-to)E482-E490
JournalCatheterization and Cardiovascular Interventions
Issue number4
StatePublished - Oct 1 2013
Externally publishedYes


  • anoxic brain injury
  • out-of-hospital cardiac arrest
  • post cardiac arrest syndrome
  • return of spontaneous circulation
  • sudden cardiac death

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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