State dynamics of the epileptic brain

Samuel P. Burns, Sabato Santaniello, William S. Anderson, Sridevi V. Sarma

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Communication between specialized regions of the brain is a dynamic process allowing for different connections to accomplish different tasks. While the content of interregional communication is complex, the pattern of connectivity (i.e., which regions communicate) may lie in a lower dimensional state-space. In epilepsy, seizures elicit changes in connectivity, whose patterns shed insight into the nature of seizures and the seizure focus. We investigated connectivity in 3 patients by applying network-based analysis on multi-day subdural electrocorticographic recordings (ECoG). We found that (i) the network connectivity defines a finite set of brain states, (ii) seizures are characterized by a consistent progression of states, and (iii) the focus is isolated from surrounding regions at the seizure onset and becomes most connected in the network towards seizure termination. Our results suggest that a finitedimensional state-space model may characterize the dynamics of the epileptic brain, and may ultimately be used to localize seizure foci.

Original languageEnglish (US)
Title of host publicationControl, Monitoring, and Energy Harvesting of Vibratory Systems; Cooperative and Networked Control; Delay Systems; Dynamical Modeling and Diagnostics in Biomedical Systems;
PublisherAmerican Society of Mechanical Engineers (ASME)
ISBN (Print)9780791856130
DOIs
StatePublished - Jan 1 2013
EventASME 2013 Dynamic Systems and Control Conference, DSCC 2013 - Palo Alto, CA, United States
Duration: Oct 21 2013Oct 23 2013

Publication series

NameASME 2013 Dynamic Systems and Control Conference, DSCC 2013
Volume2

Other

OtherASME 2013 Dynamic Systems and Control Conference, DSCC 2013
CountryUnited States
CityPalo Alto, CA
Period10/21/1310/23/13

ASJC Scopus subject areas

  • Control and Systems Engineering

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