Startle Modification and P50 Gating in Schizophrenia Patients and Controls: Russian Population

Zinaida I. Storozheva, Anna V. Kirenskaya, Vladimir Y. Novototsky-Vlasov, Klavdia Y. Telesheva, Mikhail Pletnikov

Research output: Contribution to journalArticle

Abstract

Prepulse modification of the acoustic startle response (ASR) and P50 gating are potential neurophysiological endophenotypes of schizophrenia and may be used in the construction of valid clinical biomarkers. Such approach requires a large amount of data obtained in the representative samples from different gender, socio-typological and ethnic groups, replicating studies using the similar protocols and meta-analyses. This is a replication study of ASR and the first study of P50 suppression in Russian patients with schizophrenia (n = 28) and healthy controls (n = 25). ASR and P50 were estimated according to standard protocols. Patients exhibited increased baseline ASR latency (d = 0.35, p = .026) and reduced prepulse inhibition (PPI) at 60 ms interval (d = 0.39, p = .003) and 120 ms interval (d = 0.37, p = .005) relative to controls. In the P50 test patients displayed greater S2 response amplitude (d = 0.24, p = .036) and deficit of P50 suppression (d = 0.43, p = .001). No correlations of PPI and P50 suppression were found in both groups. Only in controls prepulse ASR facilitation (at 2500 ms interval) positively correlated with P50 suppression (r = –.514, p = .013). In patients PPI displayed significant correlations with Difficulty in abstract thinking (N5: r = –.49, p = .005) and Hallucination (P3: r = .40, p = .036) PANSS scales. Logistic regression showed that the combination of PPI and P50 suppression could serve as a diagnostic predictor. Obtained results demonstrated that both PPI and P50 could be regarded as potential schizophrenia biomarkers in Russian population.

Original languageEnglish (US)
JournalSpanish Journal of Psychology
DOIs
StateAccepted/In press - Mar 3 2016

Fingerprint

Startle Reflex
schizophrenia
suppression
Acoustics
acoustics
Schizophrenia
Population
Biomarkers
Endophenotypes
Hallucinations
Ethnic Groups
Reaction Time
Meta-Analysis
diagnostic
ethnic group
deficit
Logistic Models
logistics
Prepulse Inhibition
Gating

Keywords

  • acoustic startle reaction
  • P50 gating
  • schizophrenia

ASJC Scopus subject areas

  • Psychology(all)
  • Language and Linguistics
  • Linguistics and Language

Cite this

Startle Modification and P50 Gating in Schizophrenia Patients and Controls : Russian Population. / Storozheva, Zinaida I.; Kirenskaya, Anna V.; Novototsky-Vlasov, Vladimir Y.; Telesheva, Klavdia Y.; Pletnikov, Mikhail.

In: Spanish Journal of Psychology, 03.03.2016.

Research output: Contribution to journalArticle

Storozheva, Zinaida I. ; Kirenskaya, Anna V. ; Novototsky-Vlasov, Vladimir Y. ; Telesheva, Klavdia Y. ; Pletnikov, Mikhail. / Startle Modification and P50 Gating in Schizophrenia Patients and Controls : Russian Population. In: Spanish Journal of Psychology. 2016.
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