Abstract
The results of several different types of investigations over the last decade clearly indicate that muscle length modulates the extent of myofilament calcium ion (Ca2+) activation. Similarly, the fiber length during a contraction, which is determined in part by the load encountered during shortening, also determines the extent of myofilament Ca2+ activation. Thus, 'contractile' or 'inotropic' state as it refers to the extent of myofilament activation can, in theory, no longer be considered independent of the muscle length, as was formerly thought to be the case. Accordingly, terms such as preload, afterload and myocardial contractile state as they pertain to cardiac muscle properties lose part of their significance in light of current knowledge.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1157-1164 |
| Number of pages | 8 |
| Journal | Journal of the American College of Cardiology |
| Volume | 10 |
| Issue number | 5 |
| State | Published - 1987 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Starling's law of the heart is explained by an intimate interaction of muscle length and myofilament calcium activation. / Lakatta, Edward.
In: Journal of the American College of Cardiology, Vol. 10, No. 5, 1987, p. 1157-1164.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Starling's law of the heart is explained by an intimate interaction of muscle length and myofilament calcium activation
AU - Lakatta, Edward
PY - 1987
Y1 - 1987
N2 - The results of several different types of investigations over the last decade clearly indicate that muscle length modulates the extent of myofilament calcium ion (Ca2+) activation. Similarly, the fiber length during a contraction, which is determined in part by the load encountered during shortening, also determines the extent of myofilament Ca2+ activation. Thus, 'contractile' or 'inotropic' state as it refers to the extent of myofilament activation can, in theory, no longer be considered independent of the muscle length, as was formerly thought to be the case. Accordingly, terms such as preload, afterload and myocardial contractile state as they pertain to cardiac muscle properties lose part of their significance in light of current knowledge.
AB - The results of several different types of investigations over the last decade clearly indicate that muscle length modulates the extent of myofilament calcium ion (Ca2+) activation. Similarly, the fiber length during a contraction, which is determined in part by the load encountered during shortening, also determines the extent of myofilament Ca2+ activation. Thus, 'contractile' or 'inotropic' state as it refers to the extent of myofilament activation can, in theory, no longer be considered independent of the muscle length, as was formerly thought to be the case. Accordingly, terms such as preload, afterload and myocardial contractile state as they pertain to cardiac muscle properties lose part of their significance in light of current knowledge.
UR - http://www.scopus.com/inward/record.url?scp=0023201095&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023201095&partnerID=8YFLogxK
M3 - Review article
C2 - 3312367
AN - SCOPUS:0023201095
VL - 10
SP - 1157
EP - 1164
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
SN - 0735-1097
IS - 5
ER -