Staphylococcus aureus biofilms: Properties, regulation and roles in human disease

Nathan K. Archer, Mark J. Mazaitis, J. William Costerton, Jeff G. Leid, Mary Elizabeth Powers, Mark E. Shirtliff

Research output: Contribution to journalReview articlepeer-review

471 Scopus citations


Increasing attention has been focused on understanding bacterial biofilms and this growth modality's relation to human disease. In this review we explore the genetic regulation and molecular components involved in biofilm formation and maturation in the context of the Gram-positive cocci, Staphylococcus aureus. In addition, we discuss diseases and host immune responses, along with current therapies associated with S. aureus biofilm infections and prevention strategies.

Original languageEnglish (US)
Pages (from-to)445-459
Number of pages15
Issue number5
StatePublished - 2011
Externally publishedYes


  • Biofilms
  • Host response
  • MRSA
  • Pathogenesis
  • Staphylococcus aureus
  • Therapy
  • Vaccine

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases


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