Staphylococcus aureus biofilms: Properties, regulation and roles in human disease

Nathan K. Archer; Mark J. Mazaitis; J. William Costerton; Jeff G. Leid; Mary Elizabeth Powers; Mark E. Shirtliff

doi:10.4161/viru.2.5.17724

Staphylococcus aureus biofilms: Properties, regulation and roles in human disease

Nathan K. Archer, Mark J. Mazaitis, J. William Costerton, Jeff G. Leid, Mary Elizabeth Powers, Mark E. Shirtliff

Research output: Contribution to journal › Review article › peer-review

471 Scopus citations

Abstract

Increasing attention has been focused on understanding bacterial biofilms and this growth modality's relation to human disease. In this review we explore the genetic regulation and molecular components involved in biofilm formation and maturation in the context of the Gram-positive cocci, Staphylococcus aureus. In addition, we discuss diseases and host immune responses, along with current therapies associated with S. aureus biofilm infections and prevention strategies.

Original language	English (US)
Pages (from-to)	445-459
Number of pages	15
Journal	Virulence
Volume	2
Issue number	5
DOIs	https://doi.org/10.4161/viru.2.5.17724
State	Published - 2011
Externally published	Yes

Keywords

Biofilms
Host response
MRSA
Pathogenesis
Staphylococcus aureus
Therapy
Vaccine

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Microbiology (medical)
Infectious Diseases

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10.4161/viru.2.5.17724

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title = "Staphylococcus aureus biofilms: Properties, regulation and roles in human disease",

abstract = "Increasing attention has been focused on understanding bacterial biofilms and this growth modality's relation to human disease. In this review we explore the genetic regulation and molecular components involved in biofilm formation and maturation in the context of the Gram-positive cocci, Staphylococcus aureus. In addition, we discuss diseases and host immune responses, along with current therapies associated with S. aureus biofilm infections and prevention strategies.",

keywords = "Biofilms, Host response, MRSA, Pathogenesis, Staphylococcus aureus, Therapy, Vaccine",

author = "Archer, {Nathan K.} and Mazaitis, {Mark J.} and {William Costerton}, J. and Leid, {Jeff G.} and Powers, {Mary Elizabeth} and Shirtliff, {Mark E.}",

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T2 - Properties, regulation and roles in human disease

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AU - William Costerton, J.

AU - Leid, Jeff G.

AU - Powers, Mary Elizabeth

AU - Shirtliff, Mark E.

PY - 2011

Y1 - 2011

N2 - Increasing attention has been focused on understanding bacterial biofilms and this growth modality's relation to human disease. In this review we explore the genetic regulation and molecular components involved in biofilm formation and maturation in the context of the Gram-positive cocci, Staphylococcus aureus. In addition, we discuss diseases and host immune responses, along with current therapies associated with S. aureus biofilm infections and prevention strategies.

AB - Increasing attention has been focused on understanding bacterial biofilms and this growth modality's relation to human disease. In this review we explore the genetic regulation and molecular components involved in biofilm formation and maturation in the context of the Gram-positive cocci, Staphylococcus aureus. In addition, we discuss diseases and host immune responses, along with current therapies associated with S. aureus biofilm infections and prevention strategies.

KW - Biofilms

KW - Host response

KW - MRSA

KW - Pathogenesis

KW - Staphylococcus aureus

KW - Therapy

KW - Vaccine

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ER -

Staphylococcus aureus biofilms: Properties, regulation and roles in human disease

Abstract

Keywords

ASJC Scopus subject areas

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