Standardized uptake values in 2-deoxy-2[18F]fluoro-D-glucose with positron emission tomography: Clinical significance of iterative reconstruction and segmented attenuation compared with conventional filtered back projection and measured attenuation correction

Bennett B. Chin, Sujatha Lyengar, Beulah Perdue Sabundayo, David Schwartz

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To evaluate the clinical significance of differences in 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography (FDG-PET) lymph node standardized uptake values (SUV) in human immunodeficiency virus (HIV) infection using iterative reconstruction with segmented attenuation correction (IR SAC) compared to filtered back-projection with measured attenuation correction (FBP MAC). Procedures: Seven patients with HIV infection and multiple focal lymph node abnormalities were investigated with whole-body FDG-PET. Mean and maximum SUVs from lymph node regions of interest (n = 961) were compared for quantitative differences between reconstruction techniques. Results: IR MAC resulted in significantly lower mean SUV [0.06; 95% (confidence interval (CI)) = 0.04-0.07] and maximum SUV (0.82; 95% CI = 0.77-0.88) values compared to FBP MAC. With IR, segmentation of attenuation correction (AC) resulted in significantly higher mean SUV (0.12; 95% CI = 0.11-0.13) and maximum SUV (0.21; 95% CI = 0.18-0.23) values compared to IR MAC. The overall effect of both IR and SAC was a slight but significant increase in mean SUV (0.06; 95% CI = 0.06-0.08; bias = 2.1%) and a significant decrease in maximum SUV (0.62; 95% CI = 0.56-0.67) compared to FBP MAC. Conclusions: With our reconstruction parameters, significant differences in mean and maximum SUV values were observed. The magnitude of the mean SUV difference, however, was small. IR SAC is a promising method to accurately quantify standardized uptake values for clinical use.

Original languageEnglish (US)
Pages (from-to)294-300
Number of pages7
JournalMolecular Imaging and Biology
Volume4
Issue number4
DOIs
StatePublished - Jan 1 2002

Keywords

  • FDG-PET
  • Iterative reconstruction
  • Segmented attenuation correction

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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