Standardized transbronchial needle aspiration procedure for intrathoracic lymph node staging of non-small cell lung cancer

Xu Ru Jin, Min Ye, Zhen Zhen Cai, Yu Ping Li, Cai Er Ye, Qiu Xiang He, Ko Wang, Cheng Shui Chen

Research output: Contribution to journalArticle

Abstract

Background: Thoracic lymph node (LN) metastasis is the determining factor for NSCLC staging. However, enlargement in thoracic LNs, which can be detected by chest computed tomography (CT), may not be adequate for NSCLC staging. This study aimed to investigate the effectiveness of a new transbronchial needle aspiration (TBNA) procedure to improve the sensitivity and accuracy of lung cancer diagnosis and staging. Methods: A standardized TBNA procedure was performed on enlarged and non-enlarged LNs in the order of N3 to N1 station according to Wang's LN map. The status of LN metastasis determined by the standardized TBNA procedure was compared with the results from CT scan. Results: The TBNA biopsy revealed that 21.43% of non-enlarged LNs were malignant. Compared with chest CT, the standardized TBNA procedure improved the accuracy of LN metastasis staging and discovered skip LN metastasis. Conclusions: The standardized TBNA procedure of this study may be recommended to be used as a routine TBNA procedure, in which LNs should be biopsied in the order of N3 to N1 station and both enlarged and non-enlarged LNs should be included to improve the accuracy of lung cancer staging.

Original languageEnglish (US)
Pages (from-to)S266-S271
JournalJournal of Thoracic Disease
Volume7
DOIs
StatePublished - 2015

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Non-Small Cell Lung Carcinoma
Needles
Lymph Nodes
Thorax
Neoplasm Metastasis
Neoplasm Staging
Tomography
Needle Biopsy
Lung Neoplasms

Keywords

  • Lung cancer
  • Staging
  • Standardized
  • Transbronchial needle aspiration (TBNA)

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Standardized transbronchial needle aspiration procedure for intrathoracic lymph node staging of non-small cell lung cancer. / Jin, Xu Ru; Ye, Min; Cai, Zhen Zhen; Li, Yu Ping; Ye, Cai Er; He, Qiu Xiang; Wang, Ko; Chen, Cheng Shui.

In: Journal of Thoracic Disease, Vol. 7, 2015, p. S266-S271.

Research output: Contribution to journalArticle

Jin, Xu Ru ; Ye, Min ; Cai, Zhen Zhen ; Li, Yu Ping ; Ye, Cai Er ; He, Qiu Xiang ; Wang, Ko ; Chen, Cheng Shui. / Standardized transbronchial needle aspiration procedure for intrathoracic lymph node staging of non-small cell lung cancer. In: Journal of Thoracic Disease. 2015 ; Vol. 7. pp. S266-S271.
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abstract = "Background: Thoracic lymph node (LN) metastasis is the determining factor for NSCLC staging. However, enlargement in thoracic LNs, which can be detected by chest computed tomography (CT), may not be adequate for NSCLC staging. This study aimed to investigate the effectiveness of a new transbronchial needle aspiration (TBNA) procedure to improve the sensitivity and accuracy of lung cancer diagnosis and staging. Methods: A standardized TBNA procedure was performed on enlarged and non-enlarged LNs in the order of N3 to N1 station according to Wang's LN map. The status of LN metastasis determined by the standardized TBNA procedure was compared with the results from CT scan. Results: The TBNA biopsy revealed that 21.43{\%} of non-enlarged LNs were malignant. Compared with chest CT, the standardized TBNA procedure improved the accuracy of LN metastasis staging and discovered skip LN metastasis. Conclusions: The standardized TBNA procedure of this study may be recommended to be used as a routine TBNA procedure, in which LNs should be biopsied in the order of N3 to N1 station and both enlarged and non-enlarged LNs should be included to improve the accuracy of lung cancer staging.",
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T1 - Standardized transbronchial needle aspiration procedure for intrathoracic lymph node staging of non-small cell lung cancer

AU - Jin, Xu Ru

AU - Ye, Min

AU - Cai, Zhen Zhen

AU - Li, Yu Ping

AU - Ye, Cai Er

AU - He, Qiu Xiang

AU - Wang, Ko

AU - Chen, Cheng Shui

PY - 2015

Y1 - 2015

N2 - Background: Thoracic lymph node (LN) metastasis is the determining factor for NSCLC staging. However, enlargement in thoracic LNs, which can be detected by chest computed tomography (CT), may not be adequate for NSCLC staging. This study aimed to investigate the effectiveness of a new transbronchial needle aspiration (TBNA) procedure to improve the sensitivity and accuracy of lung cancer diagnosis and staging. Methods: A standardized TBNA procedure was performed on enlarged and non-enlarged LNs in the order of N3 to N1 station according to Wang's LN map. The status of LN metastasis determined by the standardized TBNA procedure was compared with the results from CT scan. Results: The TBNA biopsy revealed that 21.43% of non-enlarged LNs were malignant. Compared with chest CT, the standardized TBNA procedure improved the accuracy of LN metastasis staging and discovered skip LN metastasis. Conclusions: The standardized TBNA procedure of this study may be recommended to be used as a routine TBNA procedure, in which LNs should be biopsied in the order of N3 to N1 station and both enlarged and non-enlarged LNs should be included to improve the accuracy of lung cancer staging.

AB - Background: Thoracic lymph node (LN) metastasis is the determining factor for NSCLC staging. However, enlargement in thoracic LNs, which can be detected by chest computed tomography (CT), may not be adequate for NSCLC staging. This study aimed to investigate the effectiveness of a new transbronchial needle aspiration (TBNA) procedure to improve the sensitivity and accuracy of lung cancer diagnosis and staging. Methods: A standardized TBNA procedure was performed on enlarged and non-enlarged LNs in the order of N3 to N1 station according to Wang's LN map. The status of LN metastasis determined by the standardized TBNA procedure was compared with the results from CT scan. Results: The TBNA biopsy revealed that 21.43% of non-enlarged LNs were malignant. Compared with chest CT, the standardized TBNA procedure improved the accuracy of LN metastasis staging and discovered skip LN metastasis. Conclusions: The standardized TBNA procedure of this study may be recommended to be used as a routine TBNA procedure, in which LNs should be biopsied in the order of N3 to N1 station and both enlarged and non-enlarged LNs should be included to improve the accuracy of lung cancer staging.

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KW - Staging

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