Standardized regression-based clinical change score cutoffs for normal pressure hydrocephalus

Alexander Davis, Sevil Yasar, Iris Emerman, Seema Gulyani, Kristina Khingelova, Aruna Rao, Lacie Manthripragada, Mark Luciano, Abhay Moghekar

Research output: Contribution to journalArticle

Abstract

Background: Presently, for patients presenting with suspected Normal Pressure Hydrocephalus (NPH) who undergo temporary drainage of cerebrospinal fluid (CSF) there is no defined model to differentiate chance improvement form clinical significance change at the individual patient level. To address this lack of information we computed standard regression based clinical change models for the 10 Meter Walk Test, Timed Up & Go, Dual Timed Up & Go, 6-Minute Walk Test, Mini-Balance Evaluation Systems Test, Montreal Cognitive Assessment, and Symbol Digit Modalities using data from patients with suspected NPH that underwent temporary drainage of CSF. These clinically significant change modes can classify clinically significant improvement following temporary drainage of CSF at the individual patient level. This allows for physicians to differentiate a clinically significant improvement in symptoms from chance improvement. Methods: Data was collected from 323 patients, over the age of 60, with suspected NPH that underwent temporary drainage of CSF with corresponding gait and cognitive testing. McSweeney Standardized Regression Based Clinical Change Models were computed for standard gait and cognitive measures: Timed Up & Go, Dual Timed Up & Go, 10 Meter Walk Test, MiniBESTest, 6-Minute Walk Test, Montreal Cognitive Assessment, and Symbol Digit Modalities Test. To assess the discriminate validity of the measures we used correlations, Chi2, and regression analyses. Results: The clinical change models explained 69-91.8% of the variability in post-drain performance (p < 0.001). As patient scores became more impaired, the percent change required for improvement to be clinically significant increased for all measures. We found that the measures were not discriminate, the Timed Up & Go was highly related to the 10 Meter Walk Test (r = 0.85, R 2 = 0.769-0.738, p < 0.001), MiniBESTest (r =-0.67, R 2 = 0.589-0.734, p < 0.001), and 6 Minute Walk Test (r =-0.77, R 2 = 0.71-0.734, p < 0.001). Conclusion: Standardized Regression Based Clinically Significant Change Models allow for physicians to use an evidence-based approach to differentiate clinically significant change from chance improvement at the individual patient level. The Timed Up & Go was shown to be predictive of detailed measures of gait velocity, balance, and endurance.

Original languageEnglish (US)
Article number140
JournalBMC neurology
Volume20
Issue number1
DOIs
StatePublished - Apr 16 2020

Keywords

  • Clinical Change
  • Cognition
  • Gait
  • Normal pressure hydrocephalus
  • Tests and measurements

ASJC Scopus subject areas

  • Clinical Neurology

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