Standardization of laboratory methods for the PERCH study

Amanda J. Driscoll; Ruth A. Karron; Susan C. Morpeth; Niranjan Bhat; Orin S. Levine; Henry C. Baggett; W. Abdullah Brooks; Daniel R. Feikin; Laura L. Hammitt; Stephen R.C. Howie; Maria Deloria Knoll; Karen L. Kotloff; Shabir A. Madhi; J. Anthony G. Scott; Donald M. Thea; Peter V. Adrian; Dilruba Ahmed; Muntasir Alam; Trevor P. Anderson; Martin Antonio; Vicky L. Baillie; Michel Dione; Hubert P. Endtz; Caroline Gitahi; Angela Karani; Geoffrey Kwenda; Abdoul Aziz Maiga; Jessica McClellan; Joanne L. Mitchell; Palesa Morailane; Daisy Mugo; John Mwaba; James Mwansa; Salim Mwarumba; Sammy Nyongesa; Sandra Panchalingam; Mustafizur Rahman; Pongpun Sawatwong; Boubou Tamboura; Aliou Toure; Toni Whistler; Katherine L. O'Brien; David R. Murdoch

doi:10.1093/cid/cix081

Standardization of laboratory methods for the PERCH study

Amanda J. Driscoll, Ruth A. Karron, Susan C. Morpeth, Niranjan Bhat, Orin S. Levine, Henry C. Baggett, W. Abdullah Brooks, Daniel R. Feikin, Laura L. Hammitt, Stephen R.C. Howie, Maria Deloria Knoll, Karen L. Kotloff, Shabir A. Madhi, J. Anthony G. Scott, Donald M. Thea, Peter V. Adrian, Dilruba Ahmed, Muntasir Alam, Trevor P. Anderson, Martin AntonioVicky L. Baillie, Michel Dione, Hubert P. Endtz, Caroline Gitahi, Angela Karani, Geoffrey Kwenda, Abdoul Aziz Maiga, Jessica McClellan, Joanne L. Mitchell, Palesa Morailane, Daisy Mugo, John Mwaba, James Mwansa, Salim Mwarumba, Sammy Nyongesa, Sandra Panchalingam, Mustafizur Rahman, Pongpun Sawatwong, Boubou Tamboura, Aliou Toure, Toni Whistler, Katherine L. O'Brien, David R. Murdoch

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

The Pneumonia Etiology Research for Child Health study was conducted across diverse research sites and relied on standardized clinical and laboratory methods for the accurate and meaningful interpretation of pneumonia etiology data. Blood, respiratory specimens, and urine were collected from children aged 1-5months hospitalized with severe or very severe pneumonia and community controls of the same age without severe pneumonia and were tested with an extensive array of laboratory diagnostic tests. A standardized testing algorithm and standard operating procedures were applied across all study sites. Site laboratories received uniform training, equipment, and reagents for core testing methods. Standardization was further assured by routine teleconferences, in-person meetings, site monitoring visits, and internal and external quality assurance testing. Targeted confirmatory testing and testing by specialized assays were done at a central reference laboratory.

Original language	English (US)
Pages (from-to)	S245-S252
Journal	Clinical Infectious Diseases
Volume	64
DOIs	https://doi.org/10.1093/cid/cix081
State	Published - 2017

Keywords

Laboratory
PERCH
Pneumonia
Respiratory infection

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

Access to Document

10.1093/cid/cix081

Cite this

Driscoll, A. J., Karron, R. A., Morpeth, S. C., Bhat, N., Levine, O. S., Baggett, H. C., Brooks, W. A., Feikin, D. R., Hammitt, L. L., Howie, S. R. C., Knoll, M. D., Kotloff, K. L., Madhi, S. A., Scott, J. A. G., Thea, D. M., Adrian, P. V., Ahmed, D., Alam, M., Anderson, T. P., ... Murdoch, D. R. (2017). Standardization of laboratory methods for the PERCH study. Clinical Infectious Diseases, 64, S245-S252. https://doi.org/10.1093/cid/cix081

Driscoll, AJ, Karron, RA, Morpeth, SC, Bhat, N, Levine, OS, Baggett, HC, Brooks, WA, Feikin, DR, Hammitt, LL, Howie, SRC, Knoll, MD, Kotloff, KL, Madhi, SA, Scott, JAG, Thea, DM, Adrian, PV, Ahmed, D, Alam, M, Anderson, TP, Antonio, M, Baillie, VL, Dione, M, Endtz, HP, Gitahi, C, Karani, A, Kwenda, G, Maiga, AA, McClellan, J, Mitchell, JL, Morailane, P, Mugo, D, Mwaba, J, Mwansa, J, Mwarumba, S, Nyongesa, S, Panchalingam, S, Rahman, M, Sawatwong, P, Tamboura, B, Toure, A, Whistler, T, O'Brien, KL & Murdoch, DR 2017, 'Standardization of laboratory methods for the PERCH study', Clinical Infectious Diseases, vol. 64, pp. S245-S252. https://doi.org/10.1093/cid/cix081

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abstract = "The Pneumonia Etiology Research for Child Health study was conducted across diverse research sites and relied on standardized clinical and laboratory methods for the accurate and meaningful interpretation of pneumonia etiology data. Blood, respiratory specimens, and urine were collected from children aged 1-5months hospitalized with severe or very severe pneumonia and community controls of the same age without severe pneumonia and were tested with an extensive array of laboratory diagnostic tests. A standardized testing algorithm and standard operating procedures were applied across all study sites. Site laboratories received uniform training, equipment, and reagents for core testing methods. Standardization was further assured by routine teleconferences, in-person meetings, site monitoring visits, and internal and external quality assurance testing. Targeted confirmatory testing and testing by specialized assays were done at a central reference laboratory.",

keywords = "Laboratory, PERCH, Pneumonia, Respiratory infection",

author = "Driscoll, {Amanda J.} and Karron, {Ruth A.} and Morpeth, {Susan C.} and Niranjan Bhat and Levine, {Orin S.} and Baggett, {Henry C.} and Brooks, {W. Abdullah} and Feikin, {Daniel R.} and Hammitt, {Laura L.} and Howie, {Stephen R.C.} and Knoll, {Maria Deloria} and Kotloff, {Karen L.} and Madhi, {Shabir A.} and Scott, {J. Anthony G.} and Thea, {Donald M.} and Adrian, {Peter V.} and Dilruba Ahmed and Muntasir Alam and Anderson, {Trevor P.} and Martin Antonio and Baillie, {Vicky L.} and Michel Dione and Endtz, {Hubert P.} and Caroline Gitahi and Angela Karani and Geoffrey Kwenda and Maiga, {Abdoul Aziz} and Jessica McClellan and Mitchell, {Joanne L.} and Palesa Morailane and Daisy Mugo and John Mwaba and James Mwansa and Salim Mwarumba and Sammy Nyongesa and Sandra Panchalingam and Mustafizur Rahman and Pongpun Sawatwong and Boubou Tamboura and Aliou Toure and Toni Whistler and O'Brien, {Katherine L.} and Murdoch, {David R.}",

note = "Publisher Copyright: {\textcopyright} The Author 2017.",

year = "2017",

doi = "10.1093/cid/cix081",

language = "English (US)",

volume = "64",

pages = "S245--S252",

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AU - Driscoll, Amanda J.

AU - Karron, Ruth A.

AU - Morpeth, Susan C.

AU - Bhat, Niranjan

AU - Levine, Orin S.

AU - Baggett, Henry C.

AU - Brooks, W. Abdullah

AU - Feikin, Daniel R.

AU - Hammitt, Laura L.

AU - Howie, Stephen R.C.

AU - Knoll, Maria Deloria

AU - Kotloff, Karen L.

AU - Madhi, Shabir A.

AU - Scott, J. Anthony G.

AU - Thea, Donald M.

AU - Adrian, Peter V.

AU - Ahmed, Dilruba

AU - Alam, Muntasir

AU - Anderson, Trevor P.

AU - Antonio, Martin

AU - Baillie, Vicky L.

AU - Dione, Michel

AU - Endtz, Hubert P.

AU - Gitahi, Caroline

AU - Karani, Angela

AU - Kwenda, Geoffrey

AU - Maiga, Abdoul Aziz

AU - McClellan, Jessica

AU - Mitchell, Joanne L.

AU - Morailane, Palesa

AU - Mugo, Daisy

AU - Mwaba, John

AU - Mwansa, James

AU - Mwarumba, Salim

AU - Nyongesa, Sammy

AU - Panchalingam, Sandra

AU - Rahman, Mustafizur

AU - Sawatwong, Pongpun

AU - Tamboura, Boubou

AU - Toure, Aliou

AU - Whistler, Toni

AU - O'Brien, Katherine L.

AU - Murdoch, David R.

PY - 2017

Y1 - 2017

N2 - The Pneumonia Etiology Research for Child Health study was conducted across diverse research sites and relied on standardized clinical and laboratory methods for the accurate and meaningful interpretation of pneumonia etiology data. Blood, respiratory specimens, and urine were collected from children aged 1-5months hospitalized with severe or very severe pneumonia and community controls of the same age without severe pneumonia and were tested with an extensive array of laboratory diagnostic tests. A standardized testing algorithm and standard operating procedures were applied across all study sites. Site laboratories received uniform training, equipment, and reagents for core testing methods. Standardization was further assured by routine teleconferences, in-person meetings, site monitoring visits, and internal and external quality assurance testing. Targeted confirmatory testing and testing by specialized assays were done at a central reference laboratory.

AB - The Pneumonia Etiology Research for Child Health study was conducted across diverse research sites and relied on standardized clinical and laboratory methods for the accurate and meaningful interpretation of pneumonia etiology data. Blood, respiratory specimens, and urine were collected from children aged 1-5months hospitalized with severe or very severe pneumonia and community controls of the same age without severe pneumonia and were tested with an extensive array of laboratory diagnostic tests. A standardized testing algorithm and standard operating procedures were applied across all study sites. Site laboratories received uniform training, equipment, and reagents for core testing methods. Standardization was further assured by routine teleconferences, in-person meetings, site monitoring visits, and internal and external quality assurance testing. Targeted confirmatory testing and testing by specialized assays were done at a central reference laboratory.

KW - Laboratory

KW - PERCH

KW - Pneumonia

KW - Respiratory infection

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U2 - 10.1093/cid/cix081

DO - 10.1093/cid/cix081

M3 - Article

C2 - 28575358

AN - SCOPUS:85038082486

SN - 1058-4838

VL - 64

SP - S245-S252

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

ER -

Standardization of laboratory methods for the PERCH study

Abstract

Keywords

ASJC Scopus subject areas

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