Standardization of amyloid quantitation with florbetapir standardized uptake value ratios to the Centiloid scale

Michael Navitsky, Abhinay D. Joshi, Ian Kennedy, William E. Klunk, Christopher C. Rowe, Dean F. Wong, Michael J. Pontecorvo, Mark A. Mintun, Michael D. Devous

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Klunk et al. recently proposed a means of standardizing quantitation of amyloid burden from positron emission tomography scans to a common Centiloid scale, and we have applied that method to florbetapir. Methods: Florbetapir and Pittsburgh compound B scans were acquired for 46 mixed clinical presentation subjects within 18 ± 20 days. Florbetapir and Pittsburgh compound B cortical standardized uptake value ratio (SUVr) values were well correlated for both standard Centiloid (R2 = 0.894) and Avid (R2 = 0.901) volume of interests (VOIs). The methods of Klunk et al. were applied to establish a conversion first from florbetapir SUVr values obtained using standard Centiloid VOIs to Centiloids and then from Avid VOIs (Joshi et al.) to Centiloids. Results: The equation for conversion of florbetapir SUVr from Avid VOIs to the Centiloid scale was as follows: Florbetapir Centiloids = 183 × SUVrAvid − 177. The threshold that discriminated neuropathologically verified none or sparse versus moderate to frequent plaques in autopsy-confirmed data is 24.1 Centiloids. Discussion: These findings may allow improved tracer-independent amyloid quantitation.

Original languageEnglish (US)
Pages (from-to)1565-1571
Number of pages7
JournalAlzheimer's and Dementia
Volume14
Issue number12
DOIs
StatePublished - Dec 2018

Keywords

  • Amyloid imaging
  • Centiloids
  • Florbetapir
  • Pittsburgh compound B
  • Standardization

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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