Standardization and quantification of radionuclide solid gastric-emptying studies

Harvey Ziessman, Frederic H. Fahey, Frank B. Atkins, Jonathan Tall

Research output: Contribution to journalArticle

Abstract

The purposes of this investigation were to standardize and validate a simple quantitative method for performing radionuclide solid gastric emptying that can be used for any dual-head γ-camera and to establish reference values. Methods: After eating a solid meal (egg sandwich) labeled with a radionuclide, 20 healthy volunteers (9 male, 11 female) underwent a 90-min gastric-emptying study performed with a triple-head γ-camera. Two sets of 3 simultaneous projections were acquired sequentially for 30 s each: anterior, right posterior oblique (RPO), left posterior oblique (LPO), posterior, left anterior oblique (LAO), and right anterior oblique (RAO), and this sequence was repeated continuously for 90 min. Time-activity curves were generated using a gastric region of interest for each of the views as well as the conjugate-view geometric mean (GM) data for the anterior/posterior, LAO/RPO, and RAO/LPO combinations. Quantitative parameters were determined: percentage gastric emptying (%GE) at 90 min, half-time (min) based on an exponential fit, and clearance rate (%/min) based on a linear fit. Reference values were determined on the basis of a 95% con-fidence interval of the t distribution. The results were statistically analyzed and compared. Results: The %GE reference values were greater for the anterior/posterior GM (≥33%) than for the LAO (≥31%) and anterior (≥30%) GMs. The 3 %GE GM methods, the 3 exponential-fit GM methods, and the 3 linear-fit GM methods had high correlation coefficients (r ≥ 0.874), and with only a single exception, there was no statistical difference among them. The LAO method and LAO/RPO GM mean method correlated strongly (r = 0.900) and had similar mean values (52% vs. 51%) and reference values (29% vs. 30%). All 3 methods of GM quantification also correlated strongly, and there was no significant difference among them. Conclusion: We have described and validated a simple method for radionuclide solid gastric emptying that can be used with a dual-head γ-camera. We recommend the anterior/posterior GM method and have established reference values (≥33%).

Original languageEnglish (US)
Pages (from-to)760-764
Number of pages5
JournalJournal of Nuclear Medicine
Volume45
Issue number5
StatePublished - May 1 2004

Fingerprint

Gastric Emptying
Radioisotopes
Reference Values
Head
Ovum
Meals
Stomach
Healthy Volunteers
Eating

Keywords

  • Tc-sulfur colloid
  • Gastric emptying
  • Gastroparesis
  • Stomach

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Standardization and quantification of radionuclide solid gastric-emptying studies. / Ziessman, Harvey; Fahey, Frederic H.; Atkins, Frank B.; Tall, Jonathan.

In: Journal of Nuclear Medicine, Vol. 45, No. 5, 01.05.2004, p. 760-764.

Research output: Contribution to journalArticle

Ziessman, Harvey ; Fahey, Frederic H. ; Atkins, Frank B. ; Tall, Jonathan. / Standardization and quantification of radionuclide solid gastric-emptying studies. In: Journal of Nuclear Medicine. 2004 ; Vol. 45, No. 5. pp. 760-764.
@article{f395d0efb5d542468dad987dc57c54f1,
title = "Standardization and quantification of radionuclide solid gastric-emptying studies",
abstract = "The purposes of this investigation were to standardize and validate a simple quantitative method for performing radionuclide solid gastric emptying that can be used for any dual-head γ-camera and to establish reference values. Methods: After eating a solid meal (egg sandwich) labeled with a radionuclide, 20 healthy volunteers (9 male, 11 female) underwent a 90-min gastric-emptying study performed with a triple-head γ-camera. Two sets of 3 simultaneous projections were acquired sequentially for 30 s each: anterior, right posterior oblique (RPO), left posterior oblique (LPO), posterior, left anterior oblique (LAO), and right anterior oblique (RAO), and this sequence was repeated continuously for 90 min. Time-activity curves were generated using a gastric region of interest for each of the views as well as the conjugate-view geometric mean (GM) data for the anterior/posterior, LAO/RPO, and RAO/LPO combinations. Quantitative parameters were determined: percentage gastric emptying ({\%}GE) at 90 min, half-time (min) based on an exponential fit, and clearance rate ({\%}/min) based on a linear fit. Reference values were determined on the basis of a 95{\%} con-fidence interval of the t distribution. The results were statistically analyzed and compared. Results: The {\%}GE reference values were greater for the anterior/posterior GM (≥33{\%}) than for the LAO (≥31{\%}) and anterior (≥30{\%}) GMs. The 3 {\%}GE GM methods, the 3 exponential-fit GM methods, and the 3 linear-fit GM methods had high correlation coefficients (r ≥ 0.874), and with only a single exception, there was no statistical difference among them. The LAO method and LAO/RPO GM mean method correlated strongly (r = 0.900) and had similar mean values (52{\%} vs. 51{\%}) and reference values (29{\%} vs. 30{\%}). All 3 methods of GM quantification also correlated strongly, and there was no significant difference among them. Conclusion: We have described and validated a simple method for radionuclide solid gastric emptying that can be used with a dual-head γ-camera. We recommend the anterior/posterior GM method and have established reference values (≥33{\%}).",
keywords = "Tc-sulfur colloid, Gastric emptying, Gastroparesis, Stomach",
author = "Harvey Ziessman and Fahey, {Frederic H.} and Atkins, {Frank B.} and Jonathan Tall",
year = "2004",
month = "5",
day = "1",
language = "English (US)",
volume = "45",
pages = "760--764",
journal = "Journal of Nuclear Medicine",
issn = "0161-5505",
publisher = "Society of Nuclear Medicine Inc.",
number = "5",

}

TY - JOUR

T1 - Standardization and quantification of radionuclide solid gastric-emptying studies

AU - Ziessman, Harvey

AU - Fahey, Frederic H.

AU - Atkins, Frank B.

AU - Tall, Jonathan

PY - 2004/5/1

Y1 - 2004/5/1

N2 - The purposes of this investigation were to standardize and validate a simple quantitative method for performing radionuclide solid gastric emptying that can be used for any dual-head γ-camera and to establish reference values. Methods: After eating a solid meal (egg sandwich) labeled with a radionuclide, 20 healthy volunteers (9 male, 11 female) underwent a 90-min gastric-emptying study performed with a triple-head γ-camera. Two sets of 3 simultaneous projections were acquired sequentially for 30 s each: anterior, right posterior oblique (RPO), left posterior oblique (LPO), posterior, left anterior oblique (LAO), and right anterior oblique (RAO), and this sequence was repeated continuously for 90 min. Time-activity curves were generated using a gastric region of interest for each of the views as well as the conjugate-view geometric mean (GM) data for the anterior/posterior, LAO/RPO, and RAO/LPO combinations. Quantitative parameters were determined: percentage gastric emptying (%GE) at 90 min, half-time (min) based on an exponential fit, and clearance rate (%/min) based on a linear fit. Reference values were determined on the basis of a 95% con-fidence interval of the t distribution. The results were statistically analyzed and compared. Results: The %GE reference values were greater for the anterior/posterior GM (≥33%) than for the LAO (≥31%) and anterior (≥30%) GMs. The 3 %GE GM methods, the 3 exponential-fit GM methods, and the 3 linear-fit GM methods had high correlation coefficients (r ≥ 0.874), and with only a single exception, there was no statistical difference among them. The LAO method and LAO/RPO GM mean method correlated strongly (r = 0.900) and had similar mean values (52% vs. 51%) and reference values (29% vs. 30%). All 3 methods of GM quantification also correlated strongly, and there was no significant difference among them. Conclusion: We have described and validated a simple method for radionuclide solid gastric emptying that can be used with a dual-head γ-camera. We recommend the anterior/posterior GM method and have established reference values (≥33%).

AB - The purposes of this investigation were to standardize and validate a simple quantitative method for performing radionuclide solid gastric emptying that can be used for any dual-head γ-camera and to establish reference values. Methods: After eating a solid meal (egg sandwich) labeled with a radionuclide, 20 healthy volunteers (9 male, 11 female) underwent a 90-min gastric-emptying study performed with a triple-head γ-camera. Two sets of 3 simultaneous projections were acquired sequentially for 30 s each: anterior, right posterior oblique (RPO), left posterior oblique (LPO), posterior, left anterior oblique (LAO), and right anterior oblique (RAO), and this sequence was repeated continuously for 90 min. Time-activity curves were generated using a gastric region of interest for each of the views as well as the conjugate-view geometric mean (GM) data for the anterior/posterior, LAO/RPO, and RAO/LPO combinations. Quantitative parameters were determined: percentage gastric emptying (%GE) at 90 min, half-time (min) based on an exponential fit, and clearance rate (%/min) based on a linear fit. Reference values were determined on the basis of a 95% con-fidence interval of the t distribution. The results were statistically analyzed and compared. Results: The %GE reference values were greater for the anterior/posterior GM (≥33%) than for the LAO (≥31%) and anterior (≥30%) GMs. The 3 %GE GM methods, the 3 exponential-fit GM methods, and the 3 linear-fit GM methods had high correlation coefficients (r ≥ 0.874), and with only a single exception, there was no statistical difference among them. The LAO method and LAO/RPO GM mean method correlated strongly (r = 0.900) and had similar mean values (52% vs. 51%) and reference values (29% vs. 30%). All 3 methods of GM quantification also correlated strongly, and there was no significant difference among them. Conclusion: We have described and validated a simple method for radionuclide solid gastric emptying that can be used with a dual-head γ-camera. We recommend the anterior/posterior GM method and have established reference values (≥33%).

KW - Tc-sulfur colloid

KW - Gastric emptying

KW - Gastroparesis

KW - Stomach

UR - http://www.scopus.com/inward/record.url?scp=2642568644&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2642568644&partnerID=8YFLogxK

M3 - Article

C2 - 15136623

AN - SCOPUS:2642568644

VL - 45

SP - 760

EP - 764

JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

SN - 0161-5505

IS - 5

ER -