Staged versus one-time complete revascularization with percutaneous coronary intervention for multivessel coronary artery disease patients without ST-elevation myocardial infarction

Edward L. Hannan, Zaza Samadashvili, Gary D Walford, Alice K. Jacobs, Nicholas J. Stamato, Ferdinand J. Venditti, David R. Holmes, Samin Sharma, Spencer B. King

Research output: Contribution to journalArticle

Abstract

Background-There are evidence-based guidelines for staging of patients with ST-elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI), but we are not aware of any evidence comparing the strategy of complete revascularization (CR) with PCI in the index admission versus the strategy of staging in a subsequent admission for patients with coronary artery disease without STEMI. Methods and Results-PCI patients without STEMI undergoing PCI in New York between 2007 and 2009 were separated into 2 groups: those with acute coronary syndrome but no STEMI, and those without acute coronary syndrome. For each group, patients who underwent CR in the index admission were then propensity matched to patients staged within 60 days to obtain CR based on 17 patient risk factors related to longer-term mortality, and 3-year mortality rates were compared for the propensity-matched groups. Outcomes were also compared for preselected subgroups. For propensitymatched patients without acute coronary syndrome, the all-cause mortality rates at 3 years for patients who underwent CR in the index hospitalization and patients staged for CR within 60 days of discharge were 5.62% and 5.97%, P=0.93, respectively. For propensity-matched patients with acute coronary syndrome but without STEMI, the all-cause mortality rates at 3 years for patients who underwent CR in the index hospitalization and patients staged for CR within 60 days of discharge were 6.59% and 5.92%, P=0.41, respectively. Conclusions-Patients with coronary artery disease without STEMI do not have significantly lower 3-year mortality rates with staged PCI than when they undergo CR in the index admission.

Original languageEnglish (US)
Pages (from-to)12-20
Number of pages9
JournalCirculation: Cardiovascular Interventions
Volume6
Issue number1
DOIs
StatePublished - Feb 2013

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Percutaneous Coronary Intervention
Coronary Artery Disease
Acute Coronary Syndrome
Mortality
ST Elevation Myocardial Infarction
Hospitalization
Patient Admission
Research Design
Guidelines

Keywords

  • Complete revascularization
  • Multivessel disease
  • PCI
  • Staging

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Staged versus one-time complete revascularization with percutaneous coronary intervention for multivessel coronary artery disease patients without ST-elevation myocardial infarction. / Hannan, Edward L.; Samadashvili, Zaza; Walford, Gary D; Jacobs, Alice K.; Stamato, Nicholas J.; Venditti, Ferdinand J.; Holmes, David R.; Sharma, Samin; King, Spencer B.

In: Circulation: Cardiovascular Interventions, Vol. 6, No. 1, 02.2013, p. 12-20.

Research output: Contribution to journalArticle

Hannan, Edward L. ; Samadashvili, Zaza ; Walford, Gary D ; Jacobs, Alice K. ; Stamato, Nicholas J. ; Venditti, Ferdinand J. ; Holmes, David R. ; Sharma, Samin ; King, Spencer B. / Staged versus one-time complete revascularization with percutaneous coronary intervention for multivessel coronary artery disease patients without ST-elevation myocardial infarction. In: Circulation: Cardiovascular Interventions. 2013 ; Vol. 6, No. 1. pp. 12-20.
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AU - Jacobs, Alice K.

AU - Stamato, Nicholas J.

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AU - Holmes, David R.

AU - Sharma, Samin

AU - King, Spencer B.

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