Stage-specific gametocytocidal effect in vitro of the antimalaria drug qinghaosu on Plasmodium falciparum

Nirbhay Kumar, Hong Zheng

Research output: Contribution to journalArticle

Abstract

Qinghaosu, an anti-malaria drug, has been found to kill not only asexual blood stages but also the early stages of gametocytes of Plasmodium falciparum. The effect of qinghaosu in vitro depends on the concentration of the drug as well as on the initial parasitemia level (IC50=10-20 n M with 1% initial parasitemia). Resistance of P. falciparum to other anti-malaria drugs, e.g., chloroquine and pyrimethamine, did not affect susceptibility of its asexual and sexual stages to qinghaosu. Gametocytocidal effect of qinghaosu may play a role in the interruption of malaria transmission.

Original languageEnglish (US)
Pages (from-to)214-218
Number of pages5
JournalParasitology Research
Volume76
Issue number3
DOIs
StatePublished - Mar 1990

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Plasmodium falciparum
malaria
parasitemia
Malaria
drugs
Parasitemia
Pharmaceutical Preparations
pyrimethamine
teleomorphs
chloroquine
gametocytes
anamorphs
Pyrimethamine
inhibitory concentration 50
Chloroquine
Inhibitory Concentration 50
blood
artemisinine
In Vitro Techniques

ASJC Scopus subject areas

  • Parasitology

Cite this

Stage-specific gametocytocidal effect in vitro of the antimalaria drug qinghaosu on Plasmodium falciparum. / Kumar, Nirbhay; Zheng, Hong.

In: Parasitology Research, Vol. 76, No. 3, 03.1990, p. 214-218.

Research output: Contribution to journalArticle

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