TY - JOUR
T1 - Stage I, grade 3 endometrioid adenocarcinoma of the endometrium
T2 - An analysis of clinical outcomes and patterns of recurrence
AU - Rasool, Nabila
AU - Fader, Amanda Nickles
AU - Seamon, Leigh
AU - Neubauer, Nikki L.
AU - Shahin, Fadi Abu
AU - Alexander, Heather A.
AU - Moore, Kathleen
AU - Moxley, Katherine
AU - Secord, Angeles Alvarez
AU - Kunos, Charles
AU - Rose, Peter G.
AU - O'Malley, David M.
PY - 2010/1
Y1 - 2010/1
N2 - Objective: To study patterns of recurrence and survival outcomes in patients with surgical stage I, grade 3 endometrioid adenocarcinoma of the endometrium (EA) treated with various treatment modalities. Methods: A retrospective multi-institutional study of surgical stage I, grade 3 EA patients diagnosed between1988 and 2006 was performed. Demographic, clinicopathologic, treatment and outcome data were collected. After surgery, patients were treated with either observation or radiotherapy (vaginal brachytherapy, whole pelvic or both). Results: One hundred seventy-six patients were collected with a median age of 68 years. Twenty-six (15%) were stage IA, 96 (54%) IB and 54 (31%) IC. Sixty-one patients (35%) had lymphovascular space invasion (LVSI) and a mean of 18.9 lymph nodes (LNs) was removed. Seventy-eight patients (44%) were observed while 98 (56%) were treated with radiotherapy, the majority (n = 51) receiving brachytherapy. After a median follow-up of 58 months, 20 recurrences (11%) were noted. Ninety percent of recurrences occurred in Stage IB/IC patients. The median time to recurrence was 22.5 months (5-74.5) and 80% of recurrences were extra-pelvic. There was no significant difference in recurrence based upon treatment modality or LVSI. Majority of recurrences were not salvaged as 75% (12/16) died of their disease with a median time of recurrence to death of 8 months. Conclusions: Patients with stage IB/IC, grade 3 endometrioid adenocarcinoma have a significant risk for extra-pelvic recurrence. Most patients will not be salvaged and will succumb to their disease, suggesting that current loco-regional adjuvant treatment strategies are not optimal and evaluation of more systemic therapies is warranted.
AB - Objective: To study patterns of recurrence and survival outcomes in patients with surgical stage I, grade 3 endometrioid adenocarcinoma of the endometrium (EA) treated with various treatment modalities. Methods: A retrospective multi-institutional study of surgical stage I, grade 3 EA patients diagnosed between1988 and 2006 was performed. Demographic, clinicopathologic, treatment and outcome data were collected. After surgery, patients were treated with either observation or radiotherapy (vaginal brachytherapy, whole pelvic or both). Results: One hundred seventy-six patients were collected with a median age of 68 years. Twenty-six (15%) were stage IA, 96 (54%) IB and 54 (31%) IC. Sixty-one patients (35%) had lymphovascular space invasion (LVSI) and a mean of 18.9 lymph nodes (LNs) was removed. Seventy-eight patients (44%) were observed while 98 (56%) were treated with radiotherapy, the majority (n = 51) receiving brachytherapy. After a median follow-up of 58 months, 20 recurrences (11%) were noted. Ninety percent of recurrences occurred in Stage IB/IC patients. The median time to recurrence was 22.5 months (5-74.5) and 80% of recurrences were extra-pelvic. There was no significant difference in recurrence based upon treatment modality or LVSI. Majority of recurrences were not salvaged as 75% (12/16) died of their disease with a median time of recurrence to death of 8 months. Conclusions: Patients with stage IB/IC, grade 3 endometrioid adenocarcinoma have a significant risk for extra-pelvic recurrence. Most patients will not be salvaged and will succumb to their disease, suggesting that current loco-regional adjuvant treatment strategies are not optimal and evaluation of more systemic therapies is warranted.
KW - Adjuvant radiotherapy
KW - Endometrial cancer
KW - Extra-pelvic recurrence
KW - Grade 3
KW - Patterns of recurrence
KW - Stage I
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U2 - 10.1016/j.ygyno.2009.10.043
DO - 10.1016/j.ygyno.2009.10.043
M3 - Article
C2 - 19875158
AN - SCOPUS:70749090439
SN - 0090-8258
VL - 116
SP - 10
EP - 14
JO - Gynecologic oncology
JF - Gynecologic oncology
IS - 1
ER -