@article{7850b8a160c247078819d6743e0fa546,
title = "Stable Latent HIV Infection and Low-level Viremia Despite Treatment with the Broadly Neutralizing Antibody VRC07-523LS and the Latency Reversal Agent Vorinostat",
abstract = "We tested the combination of a broadly neutralizing HIV antibody with the latency reversal agent vorinostat (VOR). Eight participants received 2 month-long cycles of VRC07-523LS with VOR. Low-level viremia, resting CD4+ T-cell-associated HIV RNA (rca-RNA) was measured, and intact proviral DNA assay (IPDA) and quantitative viral outgrowth assay (QVOA) were performed at baseline and posttreatment. In 3 participants, IPDA and QVOA declines were accompanied by significant declines of rca-RNA. However, no IPDA or QVOA declines clearly exceeded assay variance or natural decay. Increased resistance to VRC07-523LS was not observed. This combination therapy did not reduce viremia or the HIV reservoir.",
keywords = "HIV latency, broadly neutralizing antibody, latency reversal",
author = "Gay, {Cynthia L.} and James, {Katherine S.} and Marina Tuyishime and Falcinelli, {Shane D.} and Joseph, {Sarah B.} and Moeser, {Matthew J.} and Brigitte Allard and Kirchherr, {Jennifer L.} and Matthew Clohosey and Raines, {Samuel L.M.} and Montefiori, {David C.} and Xiaoying Shen and Gorelick, {Robert J.} and Lucio Gama and McDermott, {Adrian B.} and Koup, {Richard A.} and Mascola, {John R.} and Michelle Floris-Moore and Kuruc, {Joann D.} and Guido Ferrari and Eron, {Joseph J.} and Archin, {Nancie M.} and Margolis, {David M.}",
note = "Publisher Copyright: {\textcopyright} 2021 The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.",
year = "2022",
month = mar,
day = "1",
doi = "10.1093/infdis/jiab487",
language = "English (US)",
volume = "225",
pages = "856--861",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "5",
}