Stability of colistimethate sodium in aqueous solution

A. M. Healan, W. Gray, E. J. Fuchs, J. M. Griffiss, R. A. Salata, J. Blumer

Research output: Contribution to journalArticlepeer-review


Colistimethate sodium, increasingly used to treat multidrug-resistant Gram-negative infections, spontaneously hydrolyzes to form colistin A (polymyxin E1) and B (polymyxin E2/B) when mixed with water. High levels of these active breakdown products at the time of administration have been associated with nephrotoxicity and even death. In this study, reconstituted colistimethate sodium was shown to be stable (<1.0% colistin A/B formation) for up to 24 h when stored at 21, 0, -20, and -70°C.

Original languageEnglish (US)
Pages (from-to)6432-6433
Number of pages2
JournalAntimicrobial agents and chemotherapy
Issue number12
StatePublished - Dec 2012

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases


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