Stability of colistimethate sodium in aqueous solution

A. M. Healan; W. Gray; E. J. Fuchs; J. M. Griffiss; R. A. Salata; J. Blumer

doi:10.1128/AAC.01079-12

Stability of colistimethate sodium in aqueous solution

A. M. Healan, W. Gray, E. J. Fuchs, J. M. Griffiss, R. A. Salata, J. Blumer

School of Medicine

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Colistimethate sodium, increasingly used to treat multidrug-resistant Gram-negative infections, spontaneously hydrolyzes to form colistin A (polymyxin E1) and B (polymyxin E2/B) when mixed with water. High levels of these active breakdown products at the time of administration have been associated with nephrotoxicity and even death. In this study, reconstituted colistimethate sodium was shown to be stable (<1.0% colistin A/B formation) for up to 24 h when stored at 21, 0, -20, and -70°C.

Original language	English (US)
Pages (from-to)	6432-6433
Number of pages	2
Journal	Antimicrobial agents and chemotherapy
Volume	56
Issue number	12
DOIs	https://doi.org/10.1128/AAC.01079-12
State	Published - Dec 2012

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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abstract = "Colistimethate sodium, increasingly used to treat multidrug-resistant Gram-negative infections, spontaneously hydrolyzes to form colistin A (polymyxin E1) and B (polymyxin E2/B) when mixed with water. High levels of these active breakdown products at the time of administration have been associated with nephrotoxicity and even death. In this study, reconstituted colistimethate sodium was shown to be stable (<1.0% colistin A/B formation) for up to 24 h when stored at 21, 0, -20, and -70°C.",

author = "Healan, {A. M.} and W. Gray and Fuchs, {E. J.} and Griffiss, {J. M.} and Salata, {R. A.} and J. Blumer",

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AU - Healan, A. M.

AU - Gray, W.

AU - Fuchs, E. J.

AU - Griffiss, J. M.

AU - Salata, R. A.

AU - Blumer, J.

PY - 2012/12

Y1 - 2012/12

N2 - Colistimethate sodium, increasingly used to treat multidrug-resistant Gram-negative infections, spontaneously hydrolyzes to form colistin A (polymyxin E1) and B (polymyxin E2/B) when mixed with water. High levels of these active breakdown products at the time of administration have been associated with nephrotoxicity and even death. In this study, reconstituted colistimethate sodium was shown to be stable (<1.0% colistin A/B formation) for up to 24 h when stored at 21, 0, -20, and -70°C.

AB - Colistimethate sodium, increasingly used to treat multidrug-resistant Gram-negative infections, spontaneously hydrolyzes to form colistin A (polymyxin E1) and B (polymyxin E2/B) when mixed with water. High levels of these active breakdown products at the time of administration have been associated with nephrotoxicity and even death. In this study, reconstituted colistimethate sodium was shown to be stable (<1.0% colistin A/B formation) for up to 24 h when stored at 21, 0, -20, and -70°C.

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Stability of colistimethate sodium in aqueous solution

Abstract

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