ST3Gal-IV is a member of the β-galactoside α-2,3-sialyltransferase family, transferring sialic acid in α2,3 linkage from CMP-NeuAc preferentially to Galβ1-4GlcNAc termini, but also to Galβ1-3GlcNAc and Galβ1-3GalNAc termini on glycoproteins and glycolipids. Included among its acceptors is Lex (Galβ1-4(Fucα1-3)GlcNAc) to produce sialyl Lex, a glycan determinant important in leukocyte trafficking.
|Original language||English (US)|
|Title of host publication||Handbook of Glycosyltransferases and Related Genes, Second Edition|
|Number of pages||8|
|State||Published - Jan 1 2014|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)