ST3 beta-galactoside alpha-2,3-sialyltransferase 4 (ST3GAL4)

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

ST3Gal-IV is a member of the β-galactoside α-2,3-sialyltransferase family, transferring sialic acid in α2,3 linkage from CMP-NeuAc preferentially to Galβ1-4GlcNAc termini, but also to Galβ1-3GlcNAc and Galβ1-3GalNAc termini on glycoproteins and glycolipids. Included among its acceptors is Lex (Galβ1-4(Fucα1-3)GlcNAc) to produce sialyl Lex, a glycan determinant important in leukocyte trafficking.

Original languageEnglish (US)
Title of host publicationHandbook of Glycosyltransferases and Related Genes, Second Edition
PublisherSpringer Japan
Pages667-674
Number of pages8
Volume2
ISBN (Electronic)9784431542407
ISBN (Print)9784431542391
DOIs
StatePublished - Jan 1 2014

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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