SREBPs: Metabolic integrators in physiology and metabolism

Tae Il Jeon; Timothy F. Osborne

doi:10.1016/j.tem.2011.10.004

SREBPs: Metabolic integrators in physiology and metabolism

Tae Il Jeon, Timothy F. Osborne

Research output: Contribution to journal › Review article › peer-review

310 Scopus citations

Abstract

Recent advances have significantly increased our understanding of how sterol regulatory element binding proteins (SREBPs) are regulated at the transcriptional and post-transcriptional levels in response to cellular signaling. The phosphatidyl inositol-3-kinase (PI3K) and SREBP pathways intersect at multiple points, and recent insights demonstrate the importance of tight regulation of the PI3K pathway for regulating SREBPs in the adaptation to fluctuating dietary calorie load in the mammalian liver. In addition, genetic and genome-wide approaches highlight new functions for SREBPs in connecting lipid metabolism with other cellular processes where lipid pathway flux affects physiologic or pathophysiologic adaptation, such as cancer, steatosis, and innate immunity. This review focuses on recent advances and new roles for mammalian SREBPs in physiology and metabolism.

Original language	English (US)
Pages (from-to)	65-72
Number of pages	8
Journal	Trends in Endocrinology and Metabolism
Volume	23
Issue number	2
DOIs	https://doi.org/10.1016/j.tem.2011.10.004
State	Published - Feb 2012
Externally published	Yes

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

Access to Document

10.1016/j.tem.2011.10.004

Cite this

@article{c61a50633c6b4278a71293d5c5918989,

title = "SREBPs: Metabolic integrators in physiology and metabolism",

abstract = "Recent advances have significantly increased our understanding of how sterol regulatory element binding proteins (SREBPs) are regulated at the transcriptional and post-transcriptional levels in response to cellular signaling. The phosphatidyl inositol-3-kinase (PI3K) and SREBP pathways intersect at multiple points, and recent insights demonstrate the importance of tight regulation of the PI3K pathway for regulating SREBPs in the adaptation to fluctuating dietary calorie load in the mammalian liver. In addition, genetic and genome-wide approaches highlight new functions for SREBPs in connecting lipid metabolism with other cellular processes where lipid pathway flux affects physiologic or pathophysiologic adaptation, such as cancer, steatosis, and innate immunity. This review focuses on recent advances and new roles for mammalian SREBPs in physiology and metabolism.",

author = "Jeon, {Tae Il} and Osborne, {Timothy F.}",

note = "Funding Information: Work in the authors{\textquoteright} laboratory related to this topic is supported by grant HL48044 from the National Institutes of Health.",

year = "2012",

month = feb,

doi = "10.1016/j.tem.2011.10.004",

language = "English (US)",

volume = "23",

pages = "65--72",

journal = "Trends in Endocrinology and Metabolism",

issn = "1043-2760",

publisher = "Elsevier Inc.",

number = "2",

}

TY - JOUR

T1 - SREBPs

T2 - Metabolic integrators in physiology and metabolism

AU - Jeon, Tae Il

AU - Osborne, Timothy F.

N1 - Funding Information: Work in the authors’ laboratory related to this topic is supported by grant HL48044 from the National Institutes of Health.

PY - 2012/2

Y1 - 2012/2

N2 - Recent advances have significantly increased our understanding of how sterol regulatory element binding proteins (SREBPs) are regulated at the transcriptional and post-transcriptional levels in response to cellular signaling. The phosphatidyl inositol-3-kinase (PI3K) and SREBP pathways intersect at multiple points, and recent insights demonstrate the importance of tight regulation of the PI3K pathway for regulating SREBPs in the adaptation to fluctuating dietary calorie load in the mammalian liver. In addition, genetic and genome-wide approaches highlight new functions for SREBPs in connecting lipid metabolism with other cellular processes where lipid pathway flux affects physiologic or pathophysiologic adaptation, such as cancer, steatosis, and innate immunity. This review focuses on recent advances and new roles for mammalian SREBPs in physiology and metabolism.

AB - Recent advances have significantly increased our understanding of how sterol regulatory element binding proteins (SREBPs) are regulated at the transcriptional and post-transcriptional levels in response to cellular signaling. The phosphatidyl inositol-3-kinase (PI3K) and SREBP pathways intersect at multiple points, and recent insights demonstrate the importance of tight regulation of the PI3K pathway for regulating SREBPs in the adaptation to fluctuating dietary calorie load in the mammalian liver. In addition, genetic and genome-wide approaches highlight new functions for SREBPs in connecting lipid metabolism with other cellular processes where lipid pathway flux affects physiologic or pathophysiologic adaptation, such as cancer, steatosis, and innate immunity. This review focuses on recent advances and new roles for mammalian SREBPs in physiology and metabolism.

UR - http://www.scopus.com/inward/record.url?scp=84856471735&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84856471735&partnerID=8YFLogxK

U2 - 10.1016/j.tem.2011.10.004

DO - 10.1016/j.tem.2011.10.004

M3 - Review article

C2 - 22154484

AN - SCOPUS:84856471735

SN - 1043-2760

VL - 23

SP - 65

EP - 72

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

IS - 2

ER -

SREBPs: Metabolic integrators in physiology and metabolism

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this