Squamous carcinoma of the foot arising in association with long-standing verrucous hyperplasia in a patient with congenital lymphedema

Jonathan Ira Epstein, G. Mendelsohn

Research output: Contribution to journalArticle

Abstract

A patient is reported with congenital lymphedema who developed a squamous cell carcinoma on his affected foot. Parallels are drawn between the development of a squamous cell carcinoma with condylomatous and spindle cell features arising in a setting of long-standing verrucous hyperplasia, as seen in this patient, and the well-recognized phenomenon of angiosarcoma occurring in areas of lymphangiomatous proliferation in patients with chronic lymphedema. The importance of a random genetic mutation occurring in hyperplastic tissue in an immunologically privileged site is discussed. Additional consideration is given, in the current case, to the possibility of viral oncogenesis and the role of ulceration as a promoter factor.

Original languageEnglish (US)
Pages (from-to)943-947
Number of pages5
JournalCancer
Volume54
Issue number5
StatePublished - 1984

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Lymphedema
Hyperplasia
Foot
Squamous Cell Carcinoma
Hemangiosarcoma
Carcinogenesis
Mutation

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Squamous carcinoma of the foot arising in association with long-standing verrucous hyperplasia in a patient with congenital lymphedema. / Epstein, Jonathan Ira; Mendelsohn, G.

In: Cancer, Vol. 54, No. 5, 1984, p. 943-947.

Research output: Contribution to journalArticle

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