Squalamine inhibits angiogenesis and solid tumor growth in vivo and perturbs embryonic vasculature

Allen K. Sills, Jon I. Williams, Betty Mae Tyler, Darin S. Epstein, Eric P. Sipos, John D. Davis, Michael P. McLane, Simon Pitchford, Kimberly Cheshire, Francis H. Gannon, William A. Kinney, Tessa L. Chao, Mark Donowitz, John J Laterra, Michael Zasloff, Henry Brem

Research output: Contribution to journalArticle

Abstract

The novel aminosterol, squalamine, inhibits angiogenesis and tumor growth in multiple animal models. This effect is mediated, at least in part, by blocking mitogen-induced proliferation and migration of endothelial cells, thus preventing neovascularization of the tumor. Squalamine has no observable effect on unstimulated endothelial cells, is not directly cytotoxic to tumor cells, does not alter mitogen production by tumor cells, and has no obvious effects on the growth of newborn vertebrates. Squalamine was also found to have remarkable effects on the primitive vascular bed of the chick chorioallantoic membrane, which has striking similarities to tumor capillaries. Squalamine may thus be well suited for treatment of tumors and other diseases characterized by neovascularization in humans.

Original languageEnglish (US)
Pages (from-to)2784-2792
Number of pages9
JournalCancer Research
Volume58
Issue number13
StatePublished - Jul 1 1998

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ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Sills, A. K., Williams, J. I., Tyler, B. M., Epstein, D. S., Sipos, E. P., Davis, J. D., McLane, M. P., Pitchford, S., Cheshire, K., Gannon, F. H., Kinney, W. A., Chao, T. L., Donowitz, M., Laterra, J. J., Zasloff, M., & Brem, H. (1998). Squalamine inhibits angiogenesis and solid tumor growth in vivo and perturbs embryonic vasculature. Cancer Research, 58(13), 2784-2792.