Spousal diabetes status as a risk factor for incident type 2 diabetes

a prospective cohort study and meta-analysis

Duke Appiah, Pamela J. Schreiner, Elizabeth Selvin, Ellen W. Demerath, James S. Pankow

Research output: Contribution to journalReview article

Abstract

Aims: It is unclear if the presence of type-2 diabetes in one spouse is associated with the development of diabetes in the other spouse. We studied the concordance of diabetes among black and white participants in the Atherosclerosis Risk in Communities (ARIC) study and summarized existing studies in a meta-analysis. Methods: We conducted a prospective cohort analysis of ARIC data from 8077 married men and women (mean age 54 years) without diabetes at baseline (1987–1989). Complementary log–log models that accounted for interval censoring was used to model the hazard ratio (HR) for the association of spousal diabetes status with the incidence of diabetes. For the meta-analysis, we searched MEDLINE and EMBASE for observational studies published through December 2018 that evaluated spousal concordance for diabetes. Results: During a median follow-up of 22 years, 2512 incident cases of diabetes were recorded. In models with adjustment for general adiposity, spousal cardiometabolic factors and other diabetes risk factors, adults who had a spouse with diabetes had elevated risk for incident diabetes compared to those without a spouse diagnosed with diabetes (HR 1.20, 95% confidence interval 1.02–1.41). This association did not differ by sex or race. Summarized estimates from the 17 studies (489,798 participants from 9 countries) included in the meta-analysis showed a positive association between spousal diabetes status and the development of diabetes (Pooled odds ratio 1.88, 95% CI 1.52–2.33). Conclusions: Results from this large prospective biracial cohort and meta-analysis provides evidence that spouses of persons with diabetes are a high-risk group for diabetes.

Original languageEnglish (US)
JournalActa Diabetologica
DOIs
StatePublished - Jan 1 2019

Fingerprint

Spouses
Type 2 Diabetes Mellitus
Meta-Analysis
Cohort Studies
Prospective Studies
Atherosclerosis
Adiposity
Proportional Hazards Models
MEDLINE
Observational Studies
Odds Ratio
Confidence Intervals
Incidence

Keywords

  • Concordance
  • Epidemiology
  • Longitudinal
  • Obesity
  • Spouse
  • Type 2 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Spousal diabetes status as a risk factor for incident type 2 diabetes : a prospective cohort study and meta-analysis. / Appiah, Duke; Schreiner, Pamela J.; Selvin, Elizabeth; Demerath, Ellen W.; Pankow, James S.

In: Acta Diabetologica, 01.01.2019.

Research output: Contribution to journalReview article

@article{34e1895f5e5f4f2cbc178dc314234e84,
title = "Spousal diabetes status as a risk factor for incident type 2 diabetes: a prospective cohort study and meta-analysis",
abstract = "Aims: It is unclear if the presence of type-2 diabetes in one spouse is associated with the development of diabetes in the other spouse. We studied the concordance of diabetes among black and white participants in the Atherosclerosis Risk in Communities (ARIC) study and summarized existing studies in a meta-analysis. Methods: We conducted a prospective cohort analysis of ARIC data from 8077 married men and women (mean age 54 years) without diabetes at baseline (1987–1989). Complementary log–log models that accounted for interval censoring was used to model the hazard ratio (HR) for the association of spousal diabetes status with the incidence of diabetes. For the meta-analysis, we searched MEDLINE and EMBASE for observational studies published through December 2018 that evaluated spousal concordance for diabetes. Results: During a median follow-up of 22 years, 2512 incident cases of diabetes were recorded. In models with adjustment for general adiposity, spousal cardiometabolic factors and other diabetes risk factors, adults who had a spouse with diabetes had elevated risk for incident diabetes compared to those without a spouse diagnosed with diabetes (HR 1.20, 95{\%} confidence interval 1.02–1.41). This association did not differ by sex or race. Summarized estimates from the 17 studies (489,798 participants from 9 countries) included in the meta-analysis showed a positive association between spousal diabetes status and the development of diabetes (Pooled odds ratio 1.88, 95{\%} CI 1.52–2.33). Conclusions: Results from this large prospective biracial cohort and meta-analysis provides evidence that spouses of persons with diabetes are a high-risk group for diabetes.",
keywords = "Concordance, Epidemiology, Longitudinal, Obesity, Spouse, Type 2 diabetes",
author = "Duke Appiah and Schreiner, {Pamela J.} and Elizabeth Selvin and Demerath, {Ellen W.} and Pankow, {James S.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1007/s00592-019-01311-y",
language = "English (US)",
journal = "Acta Diabetologica",
issn = "0940-5429",
publisher = "Springer-Verlag Italia",

}

TY - JOUR

T1 - Spousal diabetes status as a risk factor for incident type 2 diabetes

T2 - a prospective cohort study and meta-analysis

AU - Appiah, Duke

AU - Schreiner, Pamela J.

AU - Selvin, Elizabeth

AU - Demerath, Ellen W.

AU - Pankow, James S.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Aims: It is unclear if the presence of type-2 diabetes in one spouse is associated with the development of diabetes in the other spouse. We studied the concordance of diabetes among black and white participants in the Atherosclerosis Risk in Communities (ARIC) study and summarized existing studies in a meta-analysis. Methods: We conducted a prospective cohort analysis of ARIC data from 8077 married men and women (mean age 54 years) without diabetes at baseline (1987–1989). Complementary log–log models that accounted for interval censoring was used to model the hazard ratio (HR) for the association of spousal diabetes status with the incidence of diabetes. For the meta-analysis, we searched MEDLINE and EMBASE for observational studies published through December 2018 that evaluated spousal concordance for diabetes. Results: During a median follow-up of 22 years, 2512 incident cases of diabetes were recorded. In models with adjustment for general adiposity, spousal cardiometabolic factors and other diabetes risk factors, adults who had a spouse with diabetes had elevated risk for incident diabetes compared to those without a spouse diagnosed with diabetes (HR 1.20, 95% confidence interval 1.02–1.41). This association did not differ by sex or race. Summarized estimates from the 17 studies (489,798 participants from 9 countries) included in the meta-analysis showed a positive association between spousal diabetes status and the development of diabetes (Pooled odds ratio 1.88, 95% CI 1.52–2.33). Conclusions: Results from this large prospective biracial cohort and meta-analysis provides evidence that spouses of persons with diabetes are a high-risk group for diabetes.

AB - Aims: It is unclear if the presence of type-2 diabetes in one spouse is associated with the development of diabetes in the other spouse. We studied the concordance of diabetes among black and white participants in the Atherosclerosis Risk in Communities (ARIC) study and summarized existing studies in a meta-analysis. Methods: We conducted a prospective cohort analysis of ARIC data from 8077 married men and women (mean age 54 years) without diabetes at baseline (1987–1989). Complementary log–log models that accounted for interval censoring was used to model the hazard ratio (HR) for the association of spousal diabetes status with the incidence of diabetes. For the meta-analysis, we searched MEDLINE and EMBASE for observational studies published through December 2018 that evaluated spousal concordance for diabetes. Results: During a median follow-up of 22 years, 2512 incident cases of diabetes were recorded. In models with adjustment for general adiposity, spousal cardiometabolic factors and other diabetes risk factors, adults who had a spouse with diabetes had elevated risk for incident diabetes compared to those without a spouse diagnosed with diabetes (HR 1.20, 95% confidence interval 1.02–1.41). This association did not differ by sex or race. Summarized estimates from the 17 studies (489,798 participants from 9 countries) included in the meta-analysis showed a positive association between spousal diabetes status and the development of diabetes (Pooled odds ratio 1.88, 95% CI 1.52–2.33). Conclusions: Results from this large prospective biracial cohort and meta-analysis provides evidence that spouses of persons with diabetes are a high-risk group for diabetes.

KW - Concordance

KW - Epidemiology

KW - Longitudinal

KW - Obesity

KW - Spouse

KW - Type 2 diabetes

UR - http://www.scopus.com/inward/record.url?scp=85063238630&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85063238630&partnerID=8YFLogxK

U2 - 10.1007/s00592-019-01311-y

DO - 10.1007/s00592-019-01311-y

M3 - Review article

JO - Acta Diabetologica

JF - Acta Diabetologica

SN - 0940-5429

ER -