Sporadic duodenal adenoma and association with colorectal neoplasia

a case-control study.

Reem Z. Sharaiha, Michelle S. Cohen, Laura Reimers, Mouen Khashab, Francis M Giardiello, Alfred I. Neugut

Research output: Contribution to journalArticle

Abstract

Sporadic duodenal adenomas are uncommon. Prior studies show that patients with sporadic duodenal adenoma have increased risk of colorectal neoplasia and should undergo colorectal screening. However, the nature of the risk, location, and type of colorectal neoplasia are not well studied. We aimed to identify the risk of colorectal neoplasia in patients who have duodenal adenomas. A retrospective case-control study was conducted to identify sporadic duodenal adenoma patients using the databases at one academic center. Colonoscopic findings including histology and location of colorectal cancer neoplasia in sporadic duodenal adenoma patients were compared with a control group of patients without duodenal adenomas who underwent both gastroduodenoscopy and colonoscopy. Hundred and two patients with sporadic duodenal adenomas or adenocarcinomas were identified. Colonoscopy was performed in 47 patients (46%), and colorectal neoplasia was present in 22 (46%). There was a significantly higher rate of colorectal neoplasia in patients with sporadic duodenal adenoma (43%) compared to the control group (24%) odds ratio 4.8, 95% confidence interval (1.7-7.4), but not for advanced colorectal adenoma (9 vs. 26%, p = 0.17). Case patients had significantly more right-sided lesions than matched controls (p = 0.02). Single-center, retrospective study. Individuals with sporadic duodenal adenomas have a significantly higher risk of colorectal neoplasia and proximal location of neoplasia. Therefore, these patients should undergo colonoscopy with particular attention to the right colon.

Original languageEnglish (US)
Pages (from-to)2523-2528
Number of pages6
JournalDigestive Diseases and Sciences
Volume59
Issue number10
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Adenoma
Case-Control Studies
Neoplasms
Colonoscopy
Control Groups
Colorectal Neoplasms
Histology
Colon
Adenocarcinoma
Retrospective Studies
Odds Ratio
Databases
Confidence Intervals

ASJC Scopus subject areas

  • Gastroenterology
  • Physiology

Cite this

Sporadic duodenal adenoma and association with colorectal neoplasia : a case-control study. / Sharaiha, Reem Z.; Cohen, Michelle S.; Reimers, Laura; Khashab, Mouen; Giardiello, Francis M; Neugut, Alfred I.

In: Digestive Diseases and Sciences, Vol. 59, No. 10, 2014, p. 2523-2528.

Research output: Contribution to journalArticle

Sharaiha, Reem Z. ; Cohen, Michelle S. ; Reimers, Laura ; Khashab, Mouen ; Giardiello, Francis M ; Neugut, Alfred I. / Sporadic duodenal adenoma and association with colorectal neoplasia : a case-control study. In: Digestive Diseases and Sciences. 2014 ; Vol. 59, No. 10. pp. 2523-2528.
@article{f1b61e62f0af421eb4f4afde74208868,
title = "Sporadic duodenal adenoma and association with colorectal neoplasia: a case-control study.",
abstract = "Sporadic duodenal adenomas are uncommon. Prior studies show that patients with sporadic duodenal adenoma have increased risk of colorectal neoplasia and should undergo colorectal screening. However, the nature of the risk, location, and type of colorectal neoplasia are not well studied. We aimed to identify the risk of colorectal neoplasia in patients who have duodenal adenomas. A retrospective case-control study was conducted to identify sporadic duodenal adenoma patients using the databases at one academic center. Colonoscopic findings including histology and location of colorectal cancer neoplasia in sporadic duodenal adenoma patients were compared with a control group of patients without duodenal adenomas who underwent both gastroduodenoscopy and colonoscopy. Hundred and two patients with sporadic duodenal adenomas or adenocarcinomas were identified. Colonoscopy was performed in 47 patients (46{\%}), and colorectal neoplasia was present in 22 (46{\%}). There was a significantly higher rate of colorectal neoplasia in patients with sporadic duodenal adenoma (43{\%}) compared to the control group (24{\%}) odds ratio 4.8, 95{\%} confidence interval (1.7-7.4), but not for advanced colorectal adenoma (9 vs. 26{\%}, p = 0.17). Case patients had significantly more right-sided lesions than matched controls (p = 0.02). Single-center, retrospective study. Individuals with sporadic duodenal adenomas have a significantly higher risk of colorectal neoplasia and proximal location of neoplasia. Therefore, these patients should undergo colonoscopy with particular attention to the right colon.",
author = "Sharaiha, {Reem Z.} and Cohen, {Michelle S.} and Laura Reimers and Mouen Khashab and Giardiello, {Francis M} and Neugut, {Alfred I.}",
year = "2014",
doi = "10.1007/s10620-014-3188-1",
language = "English (US)",
volume = "59",
pages = "2523--2528",
journal = "Digestive Diseases and Sciences",
issn = "0163-2116",
publisher = "Plenum Publishers",
number = "10",

}

TY - JOUR

T1 - Sporadic duodenal adenoma and association with colorectal neoplasia

T2 - a case-control study.

AU - Sharaiha, Reem Z.

AU - Cohen, Michelle S.

AU - Reimers, Laura

AU - Khashab, Mouen

AU - Giardiello, Francis M

AU - Neugut, Alfred I.

PY - 2014

Y1 - 2014

N2 - Sporadic duodenal adenomas are uncommon. Prior studies show that patients with sporadic duodenal adenoma have increased risk of colorectal neoplasia and should undergo colorectal screening. However, the nature of the risk, location, and type of colorectal neoplasia are not well studied. We aimed to identify the risk of colorectal neoplasia in patients who have duodenal adenomas. A retrospective case-control study was conducted to identify sporadic duodenal adenoma patients using the databases at one academic center. Colonoscopic findings including histology and location of colorectal cancer neoplasia in sporadic duodenal adenoma patients were compared with a control group of patients without duodenal adenomas who underwent both gastroduodenoscopy and colonoscopy. Hundred and two patients with sporadic duodenal adenomas or adenocarcinomas were identified. Colonoscopy was performed in 47 patients (46%), and colorectal neoplasia was present in 22 (46%). There was a significantly higher rate of colorectal neoplasia in patients with sporadic duodenal adenoma (43%) compared to the control group (24%) odds ratio 4.8, 95% confidence interval (1.7-7.4), but not for advanced colorectal adenoma (9 vs. 26%, p = 0.17). Case patients had significantly more right-sided lesions than matched controls (p = 0.02). Single-center, retrospective study. Individuals with sporadic duodenal adenomas have a significantly higher risk of colorectal neoplasia and proximal location of neoplasia. Therefore, these patients should undergo colonoscopy with particular attention to the right colon.

AB - Sporadic duodenal adenomas are uncommon. Prior studies show that patients with sporadic duodenal adenoma have increased risk of colorectal neoplasia and should undergo colorectal screening. However, the nature of the risk, location, and type of colorectal neoplasia are not well studied. We aimed to identify the risk of colorectal neoplasia in patients who have duodenal adenomas. A retrospective case-control study was conducted to identify sporadic duodenal adenoma patients using the databases at one academic center. Colonoscopic findings including histology and location of colorectal cancer neoplasia in sporadic duodenal adenoma patients were compared with a control group of patients without duodenal adenomas who underwent both gastroduodenoscopy and colonoscopy. Hundred and two patients with sporadic duodenal adenomas or adenocarcinomas were identified. Colonoscopy was performed in 47 patients (46%), and colorectal neoplasia was present in 22 (46%). There was a significantly higher rate of colorectal neoplasia in patients with sporadic duodenal adenoma (43%) compared to the control group (24%) odds ratio 4.8, 95% confidence interval (1.7-7.4), but not for advanced colorectal adenoma (9 vs. 26%, p = 0.17). Case patients had significantly more right-sided lesions than matched controls (p = 0.02). Single-center, retrospective study. Individuals with sporadic duodenal adenomas have a significantly higher risk of colorectal neoplasia and proximal location of neoplasia. Therefore, these patients should undergo colonoscopy with particular attention to the right colon.

UR - http://www.scopus.com/inward/record.url?scp=84908507583&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84908507583&partnerID=8YFLogxK

U2 - 10.1007/s10620-014-3188-1

DO - 10.1007/s10620-014-3188-1

M3 - Article

VL - 59

SP - 2523

EP - 2528

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

SN - 0163-2116

IS - 10

ER -